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Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
被引:13
|作者:
Pedrosa, Ana Catarina
[1
]
Reis-Silva, Adriana
[2
]
Pinheiro-Costa, Joao
[1
,3
]
Beato, Joao
[1
]
Freitas-da-Costa, Paulo
[1
,3
]
Falcao, Manuel S.
[1
,2
]
Falcao-Reis, Fernando
[1
,2
]
Carneiro, Angela
[1
,2
]
机构:
[1] Hosp Sao Joao, Dept Ophthalmol, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal
[2] Univ Porto, Fac Med, Dept Sense Organs, Rua Campo Alegre 823, P-4100 Oporto, Portugal
[3] Univ Porto, Fac Med, Dept Anat, Rua Campo Alegre 823, P-4100 Oporto, Portugal
来源:
CLINICAL OPHTHALMOLOGY
|
2016年
/
10卷
关键词:
age-related macular degeneration;
choroidal neovascularization;
vascular endothelial growth factor;
visual acuity;
D O I:
10.2147/OPTH.S90913
中图分类号:
R77 [眼科学];
学科分类号:
100212 ;
摘要:
Purpose: To evaluate the 5-year results obtained in clinical practice in the treatment of neovascular age-related macular degeneration (nAMD) with anti-VEGF agents. Materials and methods: We retrospectively analyzed all patients with nAMD who initiated anti-VEGF treatment before October 2009. We collected data regarding visual and anatomical outcomes. Results: A total of 278 patients met the selection criteria. The mean number of intravitreal injections was 5.7 in the first year and 3.7 in the fifth year. A positive mean visual acuity variation of +3.7 Early Treatment Diabetic Retinopathy Study letters occurred in the first year, but no significant differences relative to baseline were observed thereafter. The majority of patients (71%) maintained stable visual acuity throughout follow-up. At 5 years, mean central macular thickness remained substantially inferior to baseline (-96.6 mu m), and 56% of patients maintained dry retinas. Conclusion: Anti-VEGF therapy leads to long-term visual stabilization in the great majority of patients.
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页码:541 / 546
页数:6
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