Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes

被引:13
|
作者
Pedrosa, Ana Catarina [1 ]
Reis-Silva, Adriana [2 ]
Pinheiro-Costa, Joao [1 ,3 ]
Beato, Joao [1 ]
Freitas-da-Costa, Paulo [1 ,3 ]
Falcao, Manuel S. [1 ,2 ]
Falcao-Reis, Fernando [1 ,2 ]
Carneiro, Angela [1 ,2 ]
机构
[1] Hosp Sao Joao, Dept Ophthalmol, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal
[2] Univ Porto, Fac Med, Dept Sense Organs, Rua Campo Alegre 823, P-4100 Oporto, Portugal
[3] Univ Porto, Fac Med, Dept Anat, Rua Campo Alegre 823, P-4100 Oporto, Portugal
来源
CLINICAL OPHTHALMOLOGY | 2016年 / 10卷
关键词
age-related macular degeneration; choroidal neovascularization; vascular endothelial growth factor; visual acuity;
D O I
10.2147/OPTH.S90913
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To evaluate the 5-year results obtained in clinical practice in the treatment of neovascular age-related macular degeneration (nAMD) with anti-VEGF agents. Materials and methods: We retrospectively analyzed all patients with nAMD who initiated anti-VEGF treatment before October 2009. We collected data regarding visual and anatomical outcomes. Results: A total of 278 patients met the selection criteria. The mean number of intravitreal injections was 5.7 in the first year and 3.7 in the fifth year. A positive mean visual acuity variation of +3.7 Early Treatment Diabetic Retinopathy Study letters occurred in the first year, but no significant differences relative to baseline were observed thereafter. The majority of patients (71%) maintained stable visual acuity throughout follow-up. At 5 years, mean central macular thickness remained substantially inferior to baseline (-96.6 mu m), and 56% of patients maintained dry retinas. Conclusion: Anti-VEGF therapy leads to long-term visual stabilization in the great majority of patients.
引用
收藏
页码:541 / 546
页数:6
相关论文
共 50 条
  • [31] The Effect of Nicotine on Anti-VEGF Therapy in a Mouse Model of Neovascular Age-Related Macular Degeneration
    Davis, S. J.
    Lyzogubov, V. V.
    Tytarenko, R. G.
    Safar, A. N.
    Bora, N. S.
    Bora, P. S.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [33] Suspension of Anti-VEGF Treatment Does Not Affect Expansion of RPE Atrophy in Neovascular Age-Related Macular Degeneration
    Chujo, Shinichiro
    Matsubara, Hisashi
    Matsui, Yoshitsugu
    Sugimoto, Masahiko
    Kondo, Mineo
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (11)
  • [34] Common Variant in VEGFA and Response to Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration
    Zhao, L.
    Grob, S.
    Avery, R.
    Kimura, A.
    Pieramici, D.
    Lee, J.
    Rabena, M.
    Ortiz, S.
    Quach, J.
    Cao, G.
    Luo, H.
    Zhang, M.
    Pei, M.
    Song, Y.
    Tornambe, P.
    Goldbaum, M.
    Ferreyra, H.
    Kozak, I.
    Zhang, K.
    CURRENT MOLECULAR MEDICINE, 2013, 13 (06) : 929 - 934
  • [35] Treatment Strategies for Anti-VEGF Resistance in Neovascular Age-Related Macular Degeneration by Targeting Arteriolar Choroidal Neovascularization
    Fu, Yingbin
    Zhang, Zhao
    Webster, Keith A.
    Paulus, Yannis M.
    BIOMOLECULES, 2024, 14 (03)
  • [36] Adherence to Anti-VEGF Treatment in Patients with Neovascular Age-Related Macular Degeneration: A Real-World Study
    Shellvarajah, Mekala
    Nguyen, Vuong
    Steinmann, Sarah
    Gillies, Mark C.
    Sagkriotis, Alexandros
    Barthelmes, Daniel
    OPHTHALMOLOGY AND THERAPY, 2025, : 1261 - 1269
  • [37] Combination therapy with verteporfin and anti-VEGF agents in neovascular age-related macular degeneration: where do we stand?
    Kaiser, Peter K.
    BRITISH JOURNAL OF OPHTHALMOLOGY, 2010, 94 (02) : 143 - 145
  • [38] Effect of anti-VEGF treatment on choroidal thickness over time in patients with neovascular age-related macular degeneration
    McDonnell, Emma C.
    Heussen, Florian M.
    Ruiz-Garcia, Humberto
    Ouyang, Yanling
    Narala, Ramsudha
    Walsh, Alexander C.
    Sadda, Srinivas R.
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2014, 24 (06) : 897 - 903
  • [39] Alternative anti-VEGF treatment regimens in exudative age-related macular degeneration
    Bhisitkul, Robert B.
    Stewart, Jay M.
    EXPERT REVIEW OF OPHTHALMOLOGY, 2010, 5 (06) : 799 - 809
  • [40] Changes in Neovascular Lesion Hyperreflectivity After Anti-VEGF Treatment in Age-Related Macular Degeneration: An Integrated Multimodal Imaging Analysis
    Casalino, Giuseppe
    Bandello, Francesco
    Chakravarthy, Usha
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (09) : OCT288 - OCT298