CATHEPSIN-D IN PRIMARY SQUAMOUS LARYNGEAL TUMORS - CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS AND RECEPTOR STATUS

被引：21
作者：
FERRANDINA, G
SCAMBIA, G
PANICI, PB
ALMADORI, G
PALUDETTI, G
CADONI, G
DISTEFANO, M
MAURIZI, M
MANCUSO, S
机构：
[1] CATHOLIC UNIV ROME,DEPT OTOLARYNGOL,LGO A GEMELLI,I-800168 ROME,ITALY
[2] CATHOLIC UNIV ROME,DEPT OBSTET & GYNECOL,I-800168 ROME,ITALY
来源：
CANCER LETTERS | 1992年 / 67卷 / 2-3期
关键词：
CATHEPSIN-D; LARYNGEAL CANCER;
D O I：
10.1016/0304-3835(92)90136-J
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using an immunoradiometric assay, Cathepsin D (Cath D) levels were measured in the cytosol of 23 normal and 39 neoplastic human laryngeal tissues. Scattered Cath D levels (from 2.2 to 17.8 pM/mg protein; median = 7.6) were found in normal mucosa specimens. Cath D concentrations range from 2.0 to 29.3 pM/mg protein (median = 8.5) in laryngeal tumors. When a comparison between Cath D levels in normal and neoplastic tissue specimes from the same patient was done, Cath D levels were significantly higher in laryngeal cancers than in their normal counterparts (P = 0.03). No correlation with clinicopathological parameters and steroid hormone and epidermal growth factor receptor status was found. Further studies should investigate whether the production of Cath D by laryngeal tumors could have a clinical relevance for this neoplasia.
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收藏
页码：133 / 138
页数：6
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