INFLUENCE OF NONINHERITED MATERNAL HLA ANTIGENS ON OCCURRENCE OF RHEUMATOID-ARTHRITIS

被引:0
|
作者
TENWOLDE, S
BREEDVELD, FC
DEVRIES, RRP
DAMARO, J
RUBENSTEIN, P
SCHREUDER, GMT
CLAAS, FHJ
VANROOD, JJ
机构
[1] UNIV HOSP LEIDEN,DEPT IMMUNOHAEMATOL,POB 9600,2300 RC LEIDEN,NETHERLANDS
[2] LEIDEN UNIV HOSP,BLOOD BANK,2333 AA LEIDEN,NETHERLANDS
[3] LEIDEN UNIV HOSP,DEPT RHEUMATOL,2333 AA LEIDEN,NETHERLANDS
[4] NEW YORK BLOOD CTR,NEW YORK,NY 10021
来源
LANCET | 1993年 / 341卷 / 8839期
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many HLA-associated diseases occur in patients not carrying the putative predisposing antigen. The suggestion that this might be due to disease heterogeneity is not sufficiently supported by available data. We hypothesise that HLA-DR4-associated genetic susceptibility to rheumatoid arthritis is due to an effect of DR4 on T-cell receptor repertoire expression and that the presence of antigen in the mother is capable of producing this effect in her children, even when DR4 is not inherited by them. To investigate this possibility we HLA typed 94 rheumatoid arthritis patients and their parents and 86 control families. An increased frequency, compared with controls, of non-inherited maternal HLA-DR4 was found predominantly in the mothers of DR4-negative patients. Unexpectedly, we also found an increased frequency of non-inherited maternal HLA-DR4 and a decreased frequency of non-inherited maternal HLA-DR3 in the mothers of DR4-positive patients. The results of our analyses are consistent with our hypothesis.
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页码:200 / 202
页数:3
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