INDUCTION OF THE INTERLEUKIN-2 RECEPTOR (P55) BY INTERFERONS

被引:13
作者
ONJI, M
YAMAGUCHI, S
MASUMOTO, T
AKBAR, SMF
KAJINO, K
OHTA, Y
机构
[1] Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime
来源
JOURNAL OF INTERFERON RESEARCH | 1991年 / 11卷 / 04期
关键词
D O I
10.1089/jir.1991.11.237
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of human interferon (IFN) on the interleukin-2 receptor (IL-2R, p55) expression by peripheral blood mononuclear cells was investigated both in vitro and in vivo. IL-2R induction was assessed by the soluble IL-2R level in vitro and in vivo, which was measured by ELISA using two monoclonal antibodies to IL-2R(p55). Serum levels of sIL-2R increased significantly during IFN-alpha or IFN-beta therapy in 13 patients with chronic hepatitis B. When mononuclear cells were cultured with IFNs-alpha, -beta, or -gamma, the sIL-2R levels in the supernatant increased significantly. Dual flow cytometric analysis demonstrated that IL-2R was expressed on CD4+ and CD20+ mononuclear cells treated with IFN-alpha in vitro. CD4+ T cells and B cells may release sIL-2R when these cells are stimulated with IFN-alpha. RNA isolated from mononuclear cells treated with IFN-alpha contained increased levels of IL-2R-specific mRNA, as indicated by Northern blot analysis using an IL-2R-specific mRNA probe. These findings help to indicate how IFN plays a role in the regulation of the immune response, because IL-2R induction is known to be associated with lymphocyte activation.
引用
收藏
页码:237 / 241
页数:5
相关论文
共 20 条
  • [1] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE
    CHIRGWIN, JM
    PRZYBYLA, AE
    MACDONALD, RJ
    RUTTER, WJ
    [J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299
  • [2] EXPRESSION OF INTERLEUKIN-2 RECEPTORS AND BINDING OF INTERLEUKIN-2 BY GAMMA INTERFERON INDUCED HUMAN-LEUKEMIC AND NORMAL MONOCYTIC CELLS
    HERRMANN, F
    CANNISTRA, SA
    LEVINE, H
    GRIFFIN, JD
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (03) : 1111 - 1116
  • [3] HINUMA S, 1986, IMMUNOLOGY, V59, P251
  • [4] HOLTER W, 1987, J IMMUNOL, V138, P2917
  • [5] THE ROLE OF A GAMMA INTERFERON-LIKE LYMPHOKINE IN THE ACTIVATION OF T-CELLS FOR EXPRESSION OF INTERLEUKIN-2 RECEPTORS
    JOHNSON, HM
    FARRAR, WL
    [J]. CELLULAR IMMUNOLOGY, 1983, 75 (01) : 154 - 159
  • [6] LEE JC, 1987, J IMMUNOL, V139, P1935
  • [7] INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION IN NORMAL HUMAN LYMPHOCYTES-T
    LEONARD, WJ
    KRONKE, M
    PEFFER, NJ
    DEPPER, JM
    GREENE, WC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (18) : 6281 - 6285
  • [8] LEVIN J, 1968, THROMB DIATH HAEMOST, V19, P186
  • [9] MOLECULAR-CLONING OF CDNA-ENCODING HUMAN INTERLEUKIN-2 RECEPTOR
    NIKAIDO, T
    SHIMIZU, A
    ISHIDA, N
    SABE, H
    TESHIGAWARA, K
    MAEDA, M
    UCHIYAMA, T
    YODOI, J
    HONJO, T
    [J]. NATURE, 1984, 311 (5987) : 631 - 635
  • [10] EFFECT OF RECOMBINANT INTERLEUKIN-2 ON HEPATITIS-B E-ANTIGEN POSITIVE CHRONIC HEPATITIS
    ONJI, M
    KONDOH, H
    HORIIKE, N
    YAMAGUCHI, S
    OGAWA, Y
    KUMON, I
    OHTA, Y
    [J]. GUT, 1987, 28 (12) : 1648 - 1652