TRANSCRIPTIONAL ACTIVATION OF JUN AND ACTIN GENES BY ESTROGEN DURING MITOGENIC STIMULATION OF RAT UTERINE CELLS

被引：54

作者：

CICATIELLO, L ^{[1
]}

AMBROSINO, C ^{[1
]}

COLETTA, B ^{[1
]}

SCALONA, M ^{[1
]}

SICA, V ^{[1
]}

BRESCIANI, F ^{[1
]}

WEISZ, A ^{[1
]}

机构：

[1] NAPLES UNIV,PRIMA FAC MED & CHIRURG,IST PATOL GEN & ONCOL,PTTA S ANDREA DAME 2,I-80138 NAPLES,ITALY

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1992年 / 41卷 / 3-8期

关键词：

D O I：

10.1016/0960-0760(92)90377-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogens induce transcriptional activation of c-fos and c-myc proto-oncogenes during mitogenic stimulation of human, chicken, mouse and rat cells in vivo and in vitro. In this paper we show that 17-beta-estradiol injected into adult ovariectomized rats increases c-jun, jun-B and jun-D gene transcription in the uterus. Kinetics and amplitude of response are different for each gene, since c-jun is activated first, within 30 min after injection, followed by jun-D and jun-B, 60 and 90 min after injection, respectively. Maximal activation of jun-B marks a drop in transcription of all the jun genes. Furthermore, transcriptional activation by 17-beta-estradiol of the growth-regulated beta- and gamma-cytoskeletal actin genes is prevented by an inhibitor of protein synthesis, indicating that it is a secondary response to the hormone. These data support the hypothesis that during growth stimulation of target cells the estrogen receptor induces transcription of regulatory genes, triggering in this way a cascade of gene regulation events that results in progression through the cell cycle.

引用

页码：523 / 528

页数：6

共 27 条

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