DEPLETION OF 5-HT BY L-DOPA IN SPINAL-CORD AND BRAIN-STEM OF RAT

被引：23

作者：

COMMISSIONG, JW ^{[1
]}

SEDGWICK, EM ^{[1
]}

机构：

[1] DEPT BIOCHEM & PHYSIOL SCI,SOUTHAMPTON S09 3TU,ENGLAND

来源：

LIFE SCIENCES | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1016/0024-3205(79)90493-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intravenous L-DOPA caused a dose-dependent depletion of 5-HT in the lumbar region of rat spinal cord. Pretreatment with the peripheral decarboxylase inhibitor MK-486, significantly increased the 5-HT-depleting effect of acutely administered L-DOPA. Chronically administered L-DOPA (100 mg/kg per day for 3 days) had no effect on spinal 5-HT levels 24 hours after the last dose. It is concluded that the L-DOPA-mediated depletion of 5-HT from serotonergic terminals, already demonstrated to occur in the brain, also occurs in the spinal cord. This released 5-HT could be involved in mediating some of the observed physiological effects of L-DOPA in the spinal cord. © 1979.

引用

页码：83 / 86

页数：4

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