TOLERANCE OF FAT EMULSIONS IN VERY-LOW-BIRTH-WEIGHT NEONATES - EFFECT OF BIRTH-WEIGHT ON PLASMA-LIPID CONCENTRATIONS

被引：20

作者：

BRANS, YW

ANDREW, DS

CARRILLO, DW

DUTTON, EB

MENCHACA, EM

PULEOSCHEPPKE, BA

机构：

[1] Neonatal Research Laboratories, Departments of Pediatrics and Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, Perinatal Research Laboratory, Departments of Pediatrics and Obstetrics and Gynecology, The University of

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 1990年 / 7卷 / 02期

关键词：

D O I：

10.1055/s-2007-999459

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Plasma concentrations of various lipid fractions (total lipids, free glycerol, true triglycerides, free fatty acids, and cholesterol) were studied in 20 normally grown neonates ranging in birthweight from 820 to 1500 gm and in gestational age from 28 to 34 weeks. They were subdivided into three weight categories: 750 to 999,1000 to 1249, and 1250 to 1500 gm. A lipid emulsion was infused at a constant rate over 24 hours, beginning with an hourly infusion rate of 0.04 gm/kg and increasing each day by 0.04 gm/kg up to a maximum of 0.16 gm/kg. Neonates who weighed less than 1000 gm had higher mean plasma concentrations of total lipids and free glycerol at hourly infusion rates of 0.08 and 0.16 and of triglycerides and free fatty acids at hourly infusion rate of 0.16 gm/kg than their heavier peers. These data suggest that extreme caution be used when administering parenteral fat emulsions to neonates who weigh less than 1000 gm and that we need to monitor plasma closely for signs of hyperlipemia. © 1990, by Thieme Medical Publishers, Inc. All rights reserved.

引用

页码：114 / 117

页数：4

共 20 条

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