The Role of Coagulation in Ventilator-Associated Pneumonia

被引：1
作者：
Cortjens, Bart [1 ,2 ]
Haitsma, Jack J. [1 ,3 ]
机构：
[1] Univ Toronto, St Michaels Hosp, Interdept Div Crit Care, Toronto, ON, Canada
[2] Univ Amsterdam, Acad Med Ctr, Lab Expt Intens Care & Anesthesiol, Amsterdam, Netherlands
[3] Univ Toronto, St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Queen Wing 9-021, Toronto, ON M5S 1A1, Canada
来源：
CURRENT RESPIRATORY MEDICINE REVIEWS | 2010年 / 6卷 / 01期
关键词：
Ventilator-associated pneumonia; coagulation; mechanical ventilation; coagulopathy; ventilator-induced lung injury; anticoagulant;
D O I：
10.2174/157339810790820467
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in the intensive care unit, and it is associated with prolonged hospitalization, increased health care costs, and high attributable mortality. Inflammatory changes in the pulmonary compartment as observed in acute lung injury are also often seen in VAP, and similar observations are now made regarding pulmonary coagulation changes. In the current review we will discuss the role of these coagulation changes in VAP (coagulopathy). We will discuss how mechanical ventilation affects both VAP and coagulopathy. As well as the role of anticoagulant therapies to reduce coagulopathy; from a theoretical perspective and from limited experimental research. And finally we will outline future research in this field.
引用
收藏
页码：26 / 35
页数：10
相关论文
共 105 条
[71]   Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII [J].
Ollivier, V ;
Bentolila, S ;
Chabbat, J ;
Hakim, J ;
de Prost, D .
BLOOD, 1998, 91 (08) :2698-2703
[72]   The activity of tissue factor pathway inhibitor in experimental models of superantigen-induced shock and polymicrobial intra-abdominal sepsis [J].
Opal, SM ;
Palardy, JE ;
Parejo, NA ;
Creasey, AA .
CRITICAL CARE MEDICINE, 2001, 29 (01) :13-17
[73]   Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury [J].
Parsons, PE ;
Eisner, MD ;
Thompson, BT ;
Matthay, MA ;
Ancukiewicz, M ;
Bernard, GR ;
Wheeler, AP .
CRITICAL CARE MEDICINE, 2005, 33 (01) :1-6
[74]   Ventilator-induced lung injury and multiple system organ failure:: a critical review of facts and hypotheses [J].
Plötz, FB ;
Slutsky, AS ;
van Vught, AJ ;
Heijnen, CJ .
INTENSIVE CARE MEDICINE, 2004, 30 (10) :1865-1872
[75]   Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome [J].
Ranieri, VM ;
Giunta, F ;
Suter, PM ;
Slutsky, AS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (01) :43-44
[76]   Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome - A randomized controlled trial [J].
Ranieri, VM ;
Suter, PM ;
Tortorella, C ;
De Tullio, R ;
Dayer, JM ;
Brienza, A ;
Bruno, F ;
Slutsky, AS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (01) :54-61
[77]   REGULATION OF MURINE TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR GENE-EXPRESSION INVIVO - TISSUE-SPECIFICITY AND INDUCTION BY LIPOPOLYSACCHARIDE, TUMOR-NECROSIS-FACTOR-ALPHA, AND TRANSFORMING GROWTH-FACTOR-BETA [J].
SAWDEY, MS ;
LOSKUTOFF, DJ .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (04) :1346-1353
[78]   Evaluation of unfractionated heparin and recombinant hirudin on survival in a sustained ovine endotoxin shock model [J].
Schiffer, ERC ;
Reber, G ;
de Moerloose, P ;
Morel, DR .
CRITICAL CARE MEDICINE, 2002, 30 (12) :2689-2699
[79]   Inflammation, endothelium, and coagulation in sepsis [J].
Schouten, Marcel ;
Wiersinga, Willem Joost ;
Levi, Marcel ;
van der Poll, Tom .
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 83 (03) :536-545
[80]   Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia [J].
Schultz, MJ ;
Millo, J ;
Levi, M ;
Hack, CE ;
Weverling, GJ ;
Garrard, CS ;
van der Poll, T .
THORAX, 2004, 59 (02) :130-135
234567891011