QUANTIFYING SYSTEMIC ABSORPTION OF TOPICAL HYDROCORTISONE IN ERYTHRODERMA

被引：22

作者：

AALTOKORTE, K ^{[1
]}

TURPEINEN, M ^{[1
]}

机构：

[1] HELSINKI UNIV,CENT HOSP,DEPT ALLERG DIS,SF-00250 HELSINKI,FINLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1995年 / 133卷 / 03期

关键词：

D O I：

10.1111/j.1365-2133.1995.tb02668.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The systemic absorption of topical hydrocortisone (HC) was quantified in seven patients with erythroderma, using the ratio of the areas under the curves for plasma concentration vs. time, following topical and intravenous administration. Over a period of 24 h, 19-93 mg of HC was absorbed systemically, corresponding to 4-19% of the total topical dose of 500 mg. Thus, topical HC therapy of erythroderma is accompanied by a pharmacologically significant systemic dose.

引用

页码：403 / 408

页数：6

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