EFFECTIVENESS OF A NEW NON-THROMBOGENIC BIO-ADHESIVE IN MICROVASCULAR ANASTOMOSES

被引：9

作者：

DOWBAK, GM ^{[1
]}

ROHRICH, RJ ^{[1
]}

ROBINSON, JB ^{[1
]}

PEDEN, E ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT SURG,DIV PLAST & RECONSTRUCT SURG,DALLAS,TX 75230

来源：

JOURNAL OF RECONSTRUCTIVE MICROSURGERY | 1994年 / 10卷 / 06期

关键词：

D O I：

10.1055/s-2007-1006607

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Negatively-charged fibrin glue was successfully prepared by combining human cryoprecipitate with succinic anhydride. The resulting bio-adhesive was tested for thrombogenicity and tensile strength by applying it to three groups of Sprague-Dawley rat femoral-artery anastomoses (6 suture, 2 suture, and no suture anastomoses). Anastomoses were tested by a standard patency test over 7 days. Both the 6-suture and 2-suture anastomoses with negatively-charged fibrin glue had 100 percent patency rates and no pseudoaneurysm formation over 7 days. When positively-charged fibrin glue was applied to sutured anastomoses, patency rates decreased gradually to 50 percent over 7 days. Fibrin glue alone (whether negatively- or positively-charged) does not have the tensile strength to maintain an anastomosis without sutures. However, when applied to a two-suture anastomosis, the breaking strength of the anastomosis is more enhanced by the negatively-charged fibrin glue.

引用

页码：383 / 386

页数：4