SYNTHESIS ON SOLID PEPTIDE SUPPORTS WITH A C-TERMINAL AMINO ALCOHOL RESIDUE

被引：8
|
作者：
MOLLE, G
DUGAST, JY
机构：
[1] Laboratoire de Chimie Macromoléculaire, associé au CNRS, Faculté des Sciences de Rouen
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 44期
关键词：
D O I：
10.1016/S0040-4039(00)97062-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The solid-phase synthesis of alamethicin analogues with a γ-carboxylic group or glutamic acid was achieved by anchoring an aminoalcohol via succinic anhydride on benzhydrilamine resin. By controlling the ester interchange, an alkaline hydrolysis allowed to obtain either the Free Glu8 peptide-ol or its Glu8 methylester. © 1990.
引用
收藏
页码：6355 / 6356
页数：2
相关论文
共 50 条
  • [41] Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation
    Wang, Yen-Chih
    Distefano, Mark D.
    CHEMICAL COMMUNICATIONS, 2012, 48 (66) : 8228 - 8230
  • [42] Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a pyroglutamyl imide moiety
    Tofteng, A. Pernille
    Conde-Frieboes, Kilian W.
    Hoeg-Jensen, Thomas
    Jensen, Knud J.
    JOURNAL OF PEPTIDE SCIENCE, 2008, 14 (08) : 15 - 15
  • [43] Solid-Phase Peptide Synthesis - Evaluation of Resin Loading and Preparation of an Amide C-Terminal Dipeptide
    Nicolau, Ioana
    Paun, Anca
    Popescu, Codruta C.
    Hadade, Niculina D. D.
    Matache, Mihaela
    JOURNAL OF CHEMICAL EDUCATION, 2023, 100 (06) : 2430 - 2434
  • [44] A new Fmoc-compatible method for the solid-phase synthesis of peptide C-terminal α-thioesters
    Camarero, JA
    de Yoreo, J
    Mitchell, AR
    BIOPOLYMERS, 2003, 71 (03) : 363 - 363
  • [45] An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids
    Goldstein, AS
    Gelb, MH
    TETRAHEDRON LETTERS, 2000, 41 (16) : 2797 - 2800
  • [46] FMOC SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE THIOESTERS BY FORMATION OF A PYROGLUTAMYL IMIDE MOIETY
    Tofteng, A. P.
    Sorensen, K.
    Conde-Frieboes, K.
    Hoeg-Jensen, T. S.
    Jensen, K.
    BIOPOLYMERS, 2009, 92 (04) : 321 - 321
  • [47] DNA binding by an amino acid residue in the C-terminal half of the Rel homology region
    Liu, Jia
    Fan, Qing R.
    Sodeoka, Mikiko
    Lane, William S.
    Verdine, Gregory L.
    CHEMISTRY & BIOLOGY, 1994, 1 (01): : 47 - 55
  • [48] STUDIES ON THE AMIDE AND C-TERMINAL RESIDUES IN PROTEINS .1. CHARACTERIZATION OF THE C-TERMINAL RESIDUE
    CHIBNALL, AC
    REES, MW
    BIOCHEMICAL JOURNAL, 1958, 68 : 105 - 111
  • [49] Solid phase synthesis of C-terminal carbohydrate modified enkephalins
    Drouillat, B
    Kellam, B
    Dekany, G
    Starr, MS
    Toth, I
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (17) : 2247 - 2250
  • [50] AMINO ACID SEQUENCE OF LARGE PLAKALBUMIN PEPTIDE AND C-TERMINAL SEQUENCE OF OVALBUMIN
    THOMPSON, EO
    SLEIGH, RW
    SMITH, MB
    AUSTRALIAN JOURNAL OF BIOLOGICAL SCIENCES, 1971, 24 (03) : 525 - &
12345