ON THE STRUCTURE OF ERYTHROCYTE SPECTRIN IN PARTIALLY EXPANDED MEMBRANE SKELETONS

被引:118
作者
MCGOUGH, AM [1 ]
JOSEPHS, R [1 ]
机构
[1] UNIV CHICAGO,COMM DEV BIOL,CHICAGO,IL 60637
关键词
cytoskeleton; electron microscopy;
D O I
10.1073/pnas.87.13.5208
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Spectrin is generally believed to play an important role in the erythrocyte membrane's ability to deform elastically. We have studied the structure of negatively stained spectrin in partially expanded membrane skeletons to determine how its molecular structure confers elastic properties on the cell membrane. Fourier analysis of electron micrographs of spectrin reveal that the α and β subunits are twisted about a common axis, forming a two-start helix with twofold rotational symmetry. We propose that elastic deformation of the cell is mediated by transient extension of the helix by mechanical forces.
引用
收藏
页码:5208 / 5212
页数:5
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