TEMPERATURE-SENSITIVE MUTATIONS OF BACTERIOPHAGE-T4 LYSOZYME OCCUR AT SITES WITH LOW MOBILITY AND LOW SOLVENT ACCESSIBILITY IN THE FOLDED PROTEIN

被引：266
作者：
ALBER, T
SUN, DP
NYE, JA
MUCHMORE, DC
MATTHEWS, BW
机构：
[1] UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
[2] UNIV OREGON,DEPT PHYS,EUGENE,OR 97403
来源：
BIOCHEMISTRY | 1987年 / 26卷 / 13期
关键词：
D O I：
10.1021/bi00387a002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：3754 / 3758
页数：5
相关论文
共 44 条
[1]  
ALBER T, 1986, UCLA S MOL CELL BIOL, V39, P367
[2]  
ALBER T, 1987, IN PRESS METHODS ENZ
[3]  
BECKTEL WJ, 1987, IN PRESS BIOPOLYMERS
[4]  
BRANDTS JOHN F., 1967, P25
[5]   AN EMPIRICAL-APPROACH TO PROTEIN CONFORMATION STABILITY AND FLEXIBILITY [J].
CREIGHTON, TE .
BIOPOLYMERS, 1983, 22 (01) :49-58
[6]  
CREIGHTON TE, 1983, PROTEINS, P152
[7]   DISSECTING THE ROLES OF INDIVIDUAL INTERACTIONS IN PROTEIN STABILITY - LESSONS FROM A CIRCULARIZED PROTEIN [J].
GOLDENBERG, DP .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1985, 29 (04) :321-335
[8]  
GRAY TC, 1985, THESIS U OREGON
[9]   AMINO-ACID SUBSTITUTIONS FAR FROM THE ACTIVE-SITE OF BACTERIOPHAGE-T4 LYSOZYME REDUCE CATALYTIC ACTIVITY AND SUGGEST THAT THE C-TERMINAL LOBE OF THE ENZYME PARTICIPATES IN SUBSTRATE BINDING [J].
GRUTTER, MG ;
MATTHEWS, BW .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 154 (03) :525-535
[10]   MOLECULAR-BASIS OF THERMOSTABILITY IN THE LYSOZYME FROM BACTERIOPHAGE-T4 [J].
GRUTTER, MG ;
HAWKES, RB ;
MATTHEWS, BW .
NATURE, 1979, 277 (5698) :667-669
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