VITAMIN-D-RECEPTOR GENE POLYMORPHISMS DO NOT PREDICT BONE TURNOVER AND BONE MASS IN HEALTHY PREMENOPAUSAL WOMEN

被引:0
作者
GARNERO, P [1 ]
BOREL, O [1 ]
SORNAYRENDU, E [1 ]
DELMAS, PD [1 ]
机构
[1] HOP EDOUARD HERRIOT,INSERM,U403,F-69437 LYON 03,FRANCE
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bone mineral density (BMD) is under strong genetic control, Polymorphisms at the vitamin D receptor (VDR) gene have been recently suggested to account for up to 75% of this genetic effect, We analyzed these polymorphisms, i.e., that of BsmI, TaqI, and ApaI restriction enzymes by PCR of the DNA in 189 healthy premenopausal women aged 31 to 57 years, For the BsmI polymorphism they were 17% BE homozygotes, 51% Bb heterozygotes, and 32% bb homozygotes, genotype frequencies that are very similar to those previously reported in other Caucasian populations of north European ancestry, Women in the three genotypes for any of the three polymorphisms were matched for age and did not differ in body weight, height, physical activity, nor smoking habits. We found no relationship between the genotype for any of the three polymorphisms nor bone formation and resorption rate assessed by five specific biochemical markers of bone turnover nor with BMD measured at the spine, proximal femur, forearm, and whole body by dual-energy X-ray absorptiometry (DXA), We concluded that these polymorphisms are not predictive of bone turnover nor BMD in a sample of healthy premenopausal women drawn from the French population.
引用
收藏
页码:1283 / 1288
页数:6
相关论文
共 18 条
  • [1] GENETIC-DETERMINANTS OF BONE-MINERAL CONTENT AT THE SPINE AND RADIUS - A TWIN STUDY
    DEQUEKER, J
    NIJS, J
    VERSTRAETEN, A
    GEUSENS, P
    GEVERS, G
    [J]. BONE, 1987, 8 (04) : 207 - 209
  • [2] VITAMIN-D-RECEPTOR-GENE POLYMORPHISMS AND CHANGE IN LUMBAR-SPINE BONE-MINERAL DENSITY
    FERRARI, S
    RIZZOLI, R
    CHEVALLEY, T
    SLOSMAN, D
    EISMAN, JA
    BONJOUR, JP
    [J]. LANCET, 1995, 345 (8947): : 423 - 424
  • [3] GALLAGHER JC, 1994, J BONE MINER RES S1, V9, pS143
  • [4] GAMERO P, 1995, BONE, V16, P499
  • [5] GARNERO P, 1994, J CLIN ENDOCRINOL, V79, P78
  • [6] HANSON DA, 1992, J BONE MINER RES, V7, P1251
  • [7] BONE-MINERAL DENSITY IN RELATION TO POLYMORPHISM AT THE VITAMIN-D-RECEPTOR GENE LOCUS
    HUSTMYER, FG
    PEACOCK, M
    HUI, S
    JOHNSTON, CC
    CHRISTIAN, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (05) : 2130 - 2134
  • [8] GENETIC-FACTORS IN BONE TURNOVER
    KELLY, PJ
    HOPPER, JL
    MACASKILL, GT
    POCOCK, NA
    SAMBROOK, PN
    EISMAN, JA
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (04) : 808 - 813
  • [9] VITAMIN-D RECEPTOR GENOTYPES IN OSTEOPOROSIS
    MELHUS, H
    KINDMARK, A
    AMER, S
    WILEN, B
    LINDH, E
    LJUNGHALL, S
    [J]. LANCET, 1994, 344 (8927) : 949 - 950
  • [10] MORISSON N, 1995, BONE, V16, pS83