EVOLUTION OF PROTHROMBIN - ISOLATION AND CHARACTERIZATION OF THE CDNAS ENCODING CHICKEN AND HAGFISH PROTHROMBIN

被引：21
作者：
BANFIELD, DK
IRWIN, DM
WALZ, DA
MACGILLIVRAY, RTA
机构：
[1] UNIV BRITISH COLUMBIA, DEPT BIOCHEM, VANCOUVER V6T 1Z3, BC, CANADA
[2] WAYNE STATE UNIV, SCH MED, DEPT PHYSIOL, DETROIT, MI 48201 USA
来源：
JOURNAL OF MOLECULAR EVOLUTION | 1994年 / 38卷 / 02期
关键词：
PROTHROMBIN; CDNA; HAGFISH;
D O I：
10.1007/BF00166164
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cDNA sequences of chicken and hagfish prothrombin have been determined. The sequences predict that prothrombin from both species is synthesized as a prepro-protein consisting of a putative Gla domain, two kringle domains, and a two-chain protease domain. Chicken and hagfish prothrombin share 51.6% amino acid sequence identity (313/627 residues). Both chicken and hagfish prothrombin are structurally very similar to human, bovine, rat, and mouse prothrombin and all six species share 41% amino acid sequence identity. Amino acid sequence alignments of human, bovine, rat, mouse, chicken, and hagfish prothrombin suggest that the thrombin B-chain and the propeptide-Gla domain are the regions most constrained for the common function(s) of vertebrate prothrombins.
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页码：177 / 187
页数：11
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