BOWMAN-BIRK PROTEINASE-INHIBITOR (BBI) MODULATES RADIOSENSITIVITY AND RADIATION-INDUCED DIFFERENTIATION OF HUMAN FIBROBLASTS IN CULTURE

被引：41

作者：

DITTMANN, K ^{[1
]}

LOFFLER, H ^{[1
]}

BAMBERG, M ^{[1
]}

RODEMANN, HP ^{[1
]}

机构：

[1] UNIV TUBINGEN, DEPT RADIOTHERAPY, RADIOTHERAPY & MOLEC ENVIRONM RES SECT, D-72076 TUBINGEN, GERMANY

来源：

RADIOTHERAPY AND ONCOLOGY | 1995年 / 34卷 / 02期

关键词：

BOWMAN-BIRK PROTEINASE INHIBITOR; FIBROBLAST RADIOSENSITIVITY; FIBROBLAST DIFFERENTIATION;

D O I：

10.1016/0167-8140(94)01494-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The radiosensitivity and differentiation pattern of cultured normal human fibroblasts was analysed as a function of treatment of the cells with the Bowman-Birk proteinase inhibitor (BBI). Upon irradiation with doses from 0 to 8 Gy normal human fibroblasts are induced to a premature terminal differentiation within 14-21 days of postirradiation incubation. Treatment of the cells with 10 mu M BBI for 2 h prior to the irradiation procedure resulted in a significant shift of the radiation survival curve, increased SF2 values 0.63 vs. 0.84 and the cell type composition of the test fibroblast cultures. Upon pretreatment with BBI the radiation-induced premature terminal differentiation of progenitor fibroblasts to postmitotic fibrocytes could significantly be inhibited. Based on this data, it can be postulated that BBI may serve as a radioprotector of normal fibroblasts which are involved in radiation-induced tissue injuries like radiation fibrosis.

引用

页码：137 / 143

页数：7

共 26 条

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