STEREOCONTROLLED CONSTRUCTION OF SUBSTITUTED PYRROLIDINES BASED ON INTRAMOLECULAR PROTODESILYLATION REACTION - ENANTIOSPECIFIC SYNTHESIS OF (-)-KAINIC ACID AND (+)-ALLOKAINIC ACID FROM L-SERINE

被引：65

作者：

HATAKEYAMA, S ^{[1
]}

SUGAWARA, K ^{[1
]}

TAKANO, S ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 02期

关键词：

D O I：

10.1039/c39930000125

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel stereocontrolled enantiospecific syntheses of (-)-kainic acid and (+)-allokainic acid have been achieved starting from L-serine via two modes of C-2 and C-3 side chain-directed intramolecular protodesilylations of 4-(trimethylsilylmethyl)ethylidenepyrrolidines.

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页码：125 / 127

页数：3

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