NUCLEOTIDE-SEQUENCE COMPARISON OF THE M1 GENOME SEGMENT OF REOVIRUS TYPE-1 LANG AND TYPE-3 DEARING

被引：30

作者：

ZOU, S ^{[1
]}

BROWN, EG ^{[1
]}

机构：

[1] UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL,451 SMYTH RD,OTTAWA K1H 8M5,ONTARIO,CANADA

来源：

VIRUS RESEARCH | 1992年 / 22卷 / 02期

关键词：

REOVIRUS; TYPE-1; LANG; M1; SEGMENT; SEQUENCE;

D O I：

10.1016/0168-1702(92)90042-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mammalian reoviruses possess a genome composed of 10 double stranded RNA segments. The serotype 1 strain Lang M1 segment was sequenced and compared to the published type 3 sequence. Both segments were 2304 base-pairs long coding for the mu-2 protein predicted to be 736 amino acids long. The sequences were highly conserved with 97.2% conservation of nucleotide sequence and 98.6% conservation of amino acid sequence. The M1 segments of serotypes 1 and 3 have recently diverged as indicated by the distribution of variation with respect to codon positions. The conservation of amino acid sequence indicated that the mu-2 protein has a relatively high functional density.

引用

页码：159 / 164

页数：6

共 13 条

[1] SEQUENCES AT BOTH TERMINI OF THE 10 GENES OF REOVIRUS SEROTYPE-3 (STRAIN DEARING) [J].

ANTCZAK, JB ;

CHMELO, R ;

PICKUP, DJ ;

JOKLIK, WK .

VIROLOGY, 1982, 121 (02) :307-319

[2]

BROWN EG, 1983, DOUBLE STRANDED RNA, P275

[3] CLONING THE DOUBLE-STRANDED-RNA GENES OF REOVIRUS - SEQUENCE OF THE CLONED S2-GENE [J].

CASHDOLLAR, LW ;

ESPARZA, J ;

HUDSON, GR ;

CHMELO, R ;

LEE, PWK ;

JOKLIK, WK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7644-7648

[4] IDENTIFICATION OF THE VIRAL GENES RESPONSIBLE FOR GROWTH OF STRAINS OF REOVIRUS IN CULTURED MOUSE HEART-CELLS [J].

MATOBA, Y ;

SHERRY, B ;

FIELDS, BN ;

SMITH, TW .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05) :1628-1633

[5] THE FUNCTION OF REOVIRUS PROTEINS DURING THE REOVIRUS MULTIPLICATION CYCLE - ANALYSIS USING MONOREASSORTANTS [J].

MOODY, MD ;

JOKLIK, WK .

VIROLOGY, 1989, 173 (02) :437-446

[6] CONTROL OF REOVIRUS MESSENGER-RNA TRANSLATION EFFICIENCY BY THE REGIONS UPSTREAM OF INITIATION CODONS [J].

RONER, MR ;

GAILLARD, RK ;

JOKLIK, WK .

VIROLOGY, 1989, 168 (02) :292-301

[7] REOVIRUS RNA IS INFECTIOUS [J].

RONER, MR ;

SUTPHIN, LA ;

JOKLIK, WK .

VIROLOGY, 1990, 179 (02) :845-852

[8] A PROCEDURE FOR SELECTIVE FULL LENGTH CDNA CLONING OF SPECIFIC RNA SPECIES [J].

SCHMID, A ;

CATTANEO, R ;

BILLETER, MA .

NUCLEIC ACIDS RESEARCH, 1987, 15 (10) :3987-3996

[9] THE REOVIRUS M1 GENE, ENCODING A VIRAL CORE PROTEIN, IS ASSOCIATED WITH THE MYOCARDITIC PHENOTYPE OF A REOVIRUS VARIANT [J].

SHERRY, B ;

FIELDS, BN .

JOURNAL OF VIROLOGY, 1989, 63 (11) :4850-4856

[10]

WEINER JR, 1989, VIROLOGY, V169, P194

← 1 2 →