A GANCICLOVIR-RESISTANT CLINICAL ISOLATE OF HUMAN CYTOMEGALOVIRUS EXHIBITING CROSS-RESISTANCE TO OTHER DNA-POLYMERASE INHIBITORS

被引:76
作者
TATAROWICZ, WA
LURAIN, NS
THOMPSON, KD
机构
[1] LOYOLA UNIV,MED CTR,DEPT PATHOL,MAYWOOD,IL 60153
[2] LOYOLA UNIV,MED CTR,DEPT MICROBIOL,MAYWOOD,IL 60153
关键词
D O I
10.1093/infdis/166.4.904
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Clinical isolates of human cytomegalovirus (HCMV) were screened for susceptibility to ganciclovir by plaque-reduction assay and in situ ELISA. A pretreatment isolate of HCMV obtained from the bronchial brushing of a heart transplant recipient contained both ganciclovir-susceptible and -resistant virus. Ganciclovir-susceptible (P8) and -resistant (D16) strains were further isolated by plaque purification. Both strains phosphorylated ganciclovir at levels similar to the ganciclovir-susceptible strain AD169. D16 was also resistant to phosphonoformic acid and to (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and cytosine. These data suggest that the resistance of D16 to these drugs results from a mutation in the viral DNA polymerase gene.
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页码:904 / 907
页数:4
相关论文
共 16 条
[1]   A HUMAN CYTOMEGALOVIRUS MUTANT RESISTANT TO THE NUCLEOSIDE ANALOG 9-([2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL)GUANINE (BW B759U) INDUCES REDUCED LEVELS OF BW B759U TRIPHOSPHATE [J].
BIRON, KK ;
FYFE, JA ;
STANAT, SC ;
LESLIE, LK ;
SORRELL, JB ;
LAMBE, CU ;
COEN, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) :8769-8773
[2]   PREVALENCE OF RESISTANCE IN PATIENTS RECEIVING GANCICLOVIR FOR SERIOUS CYTOMEGALOVIRUS-INFECTION [J].
DREW, WL ;
MINER, RC ;
BUSCH, DF ;
FOLLANSBEE, SE ;
GULLETT, J ;
MEHALKO, SG ;
GORDON, SM ;
OWEN, WF ;
MATTHEWS, TR ;
BUHLES, WC ;
DEARMOND, B .
JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) :716-719
[3]   PROGRESSIVE DISEASE DUE TO GANCICLOVIR-RESISTANT CYTOMEGALO-VIRUS IN IMMUNOCOMPROMISED PATIENTS [J].
ERICE, A ;
CHOU, S ;
BIRON, KK ;
STANAT, SC ;
BALFOUR, HH ;
JORDAN, MC .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (05) :289-293
[4]   ACQUISITION OF CYTOMEGALO-VIRUS INFECTION - AN UPDATE [J].
FORBES, BA .
CLINICAL MICROBIOLOGY REVIEWS, 1989, 2 (02) :204-216
[5]   IDENTIFICATION OF AMINO-ACIDS IN HERPES-SIMPLEX VIRUS-DNA POLYMERASE INVOLVED IN SUBSTRATE AND DRUG RECOGNITION [J].
GIBBS, JS ;
CHIOU, HC ;
BASTOW, KF ;
CHENG, YC ;
COEN, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6672-6676
[6]   FOSCARNET THERAPY FOR GANCICLOVIR-RESISTANT CYTOMEGALOVIRUS RETINITIS IN PATIENTS WITH AIDS [J].
JACOBSON, MA ;
DREW, WL ;
FEINBERG, J ;
ODONNELL, JJ ;
WHITMORE, PV ;
MINER, RD ;
PARENTI, D .
JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) :1348-1351
[7]   SEQUENCE AND TRANSCRIPTION ANALYSIS OF THE HUMAN CYTOMEGALOVIRUS DNA-POLYMERASE GENE [J].
KOUZARIDES, T ;
BANKIER, AT ;
SATCHWELL, SC ;
WESTON, K ;
TOMLINSON, P ;
BARRELL, BG .
JOURNAL OF VIROLOGY, 1987, 61 (01) :125-133
[8]   ENGINEERED HERPES-SIMPLEX VIRUS-DNA POLYMERASE POINT MUTANTS - THE MOST HIGHLY CONSERVED REGION SHARED AMONG ALPHA-LIKE DNA-POLYMERASES IS INVOLVED IN SUBSTRATE RECOGNITION [J].
MARCY, AI ;
HWANG, CBC ;
RUFFNER, KL ;
COEN, DM .
JOURNAL OF VIROLOGY, 1990, 64 (12) :5883-5890
[9]  
MATTHEWS T, 1988, REV INFECT DIS, V10, pS490
[10]   ANTIVIRAL EFFECTS OF PHOSPHONOFORMATE (PFA, FOSCARNET SODIUM) [J].
OBERG, B .
PHARMACOLOGY & THERAPEUTICS, 1989, 40 (02) :213-285