SYNTHESIS OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

被引：4

作者：

BADAWEY, ESAM ^{[1
]}

HASSAN, AMM ^{[1
]}

KAPPE, T ^{[1
]}

机构：

[1] GRAZ UNIV,INST ORGAN CHEM,ORGAN SYNTH ABT,A-8010 GRAZ,AUSTRIA

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 06期

关键词：

D O I：

10.1002/ardp.19913240607

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N'-disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b. On the other hand, reaction of 1a with ethoxycarbonyl isocyanate (4) yielded the substituted s-triazine-2,4,6(1H,3H,5H)-trione 5. The reaction of 4 with 2-aminomethyl-benzimidazole (6) gave the allophanate 7 which upon treatment with Na2CO3 yielded N-(1H-benzimidazol-2-yl)urea 8.

引用

页码：355 / 357

页数：3

共 11 条

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