TARGETING OF CYTOTOXIC AGENTS BY POLYAMINES - SYNTHESIS OF A CHLORAMBUCIL SPERMIDINE CONJUGATE

被引：73
作者：
COHEN, GM
CULLIS, PM
HARTLEY, JA
MATHER, A
SYMONS, MCR
WHEELHOUSE, RT
机构：
[1] UNIV LEICESTER, DEPT CHEM, LEICESTER LE1 7RH, ENGLAND
[2] MRC, TOXICOL UNIT, CARSHALTON SM5 4EF, SURREY, ENGLAND
[3] UNIV COLL & MIDDLESEX SCH MED, DEPT ONCOL, LONDON W1P 8BT, ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 04期
关键词：
D O I：
10.1039/c39920000298
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient synthesis of the chlorambucil-spermidine conjugate 4 has been achieved via N1,N8-bis-Boc-spermidine and 4 has been shown to crosslink DNA 10(4) times more efficiently than chlorambucil itself.
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页码：298 / 300
页数：3
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