TARGETING OF CYTOTOXIC AGENTS BY POLYAMINES - SYNTHESIS OF A CHLORAMBUCIL SPERMIDINE CONJUGATE

被引：73

作者：

COHEN, GM

CULLIS, PM

HARTLEY, JA

MATHER, A

SYMONS, MCR

WHEELHOUSE, RT

机构：

[1] UNIV LEICESTER, DEPT CHEM, LEICESTER LE1 7RH, ENGLAND

[2] MRC, TOXICOL UNIT, CARSHALTON SM5 4EF, SURREY, ENGLAND

[3] UNIV COLL & MIDDLESEX SCH MED, DEPT ONCOL, LONDON W1P 8BT, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 04期

关键词：

D O I：

10.1039/c39920000298

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of the chlorambucil-spermidine conjugate 4 has been achieved via N1,N8-bis-Boc-spermidine and 4 has been shown to crosslink DNA 10(4) times more efficiently than chlorambucil itself.

引用

页码：298 / 300

页数：3

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