Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part I: Topical Treatments

被引：8
|
作者：
Gracia-Cazana, T. [1 ,2 ]
Gonzalez, S. [3 ,4 ]
Gilaberte, Y. [2 ,5 ]
机构：
[1] Hosp Barbastro, Unidad Dermatol, Barbastro, Huesca, Spain
[2] Inst Aragones Ciencias Salud, Zaragoza, Spain
[3] Mem Sloan Kettering Canc Ctr, Serv Dermatol, Nueva York, NY USA
[4] Univ Alcala, Dept Med, Madrid, Spain
[5] Hosp San Jorge, Unidad Dermatol, Huesca, Spain
来源：
ACTAS DERMO-SIFILIOGRAFICAS | 2016年 / 107卷 / 09期
关键词：
Skin cancer; Imiquimod; 5-Fluorouracil; Diclofenac; Ingenol;
D O I：
10.1016/j.ad.2016.04.019
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A wide range of treatments is now available for nonmelanoma skin cancer (NMSC), including 5-fluorouracil, ingenol mebutate, imiquimod, diclofenac, photodynamic therapy, methotrexate, cetuximab, vismodegib, and radiotherapy. All are associated with high clinical and histologic response rates. However, some tumors do not respond due to resistance, which may be primary or acquired. Study of the resistance processes is a broad area of research that aims to increase our understanding of the nature of each tumor and the biologic features that make it resistant, as well as to facilitate the design of new therapies directed against these tumors. In this article we review resistance to the authorized topical treatments for NMSC. (C) 2016 AEDV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：730 / 739
页数：10
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