SCHIZOPHRENIA - AGE AT ONSET, GENDER AND FAMILIAL RISK

被引：67

作者：

PULVER, AE

BROWN, CH

WOLYNIEC, P

MCGRATH, J

TAM, D

ADLER, L

CARPENTER, WT

CHILDS, B

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT BIOSTAT,BALTIMORE,MD 21218

[3] UNIV MARYLAND,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21201

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 82卷 / 05期

关键词：

age at onset; family; Key words; schizophrenia; sex difference;

D O I：

10.1111/j.1600-0447.1990.tb01399.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a family history study of 366 schizophrenic probands and their 1851 first‐degree relatives, we found a relationship between age at onset of psychosis in the male probands and the risk for schizophrenia in their relatives. The relatives of male schizophrenic probands whose onset of psychosis occurred when they were younger than 17 years of age had an increased risk of schizophrenia when compared with the relatives of male probands with an age at onset greater than 17. We did not find an association between age at onset of psychosis in the female probands and familial risk. Cox proportional hazards models permitted us to examine the relationship between age at onset of psychosis in the probands and familial risk while controlling for possible confounding effects. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：344 / 351

页数：8