Bisphosphonate-Associated Osteonecrosis of the Jaw: Are We Dealing with a Localized Non-Traditional Calciphylaxis?

被引：5
|
作者：
Meiller, T. F. [1 ,2 ]
Almubarak, H. [2 ]
Weikel, D. S. [1 ,2 ]
Brahim, J. [1 ,3 ]
Scheper, M. A. [1 ,2 ]
机构：
[1] Univ Maryland, Med Ctr, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA
[2] Univ Maryland, Dept Oncol & Diagnost Sci, Baltimore, MD 21201 USA
[3] Univ Maryland, Dept Oral & Maxillofacial Surg, Baltimore, MD 21201 USA
来源：
OPEN DENTISTRY JOURNAL | 2012年 / 6卷
关键词：
Bisphosphonate; bisphosphonate-associated osteonecrosis of the jaw; calciphylaxis; oncology; onj; therapeutic complications;
D O I：
10.2174/1874210601206010005
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The bisphosphonate (BP) family of drugs has been used as a vital component in cancer therapy and many other diseases. One of the main adverse effects related to (BP) is BP-associated osteonecrosis of the jaw (ONJ). Although this condition was first recognized in 2003, the pathophysiologic mechanism remains undefined. Our hypothesis is that ONJs clinical course and delayed wound healing is in part correlated to a localized non-traditional calciphylaxis. This effect is identified by the evidence of calcium deposition in the connective tissue and around small blood vessels in the soft tissues immediately adjacent to ONJ lesions. This phenomenon helps to fill gaps in the cascade of events which leads to soft tissue ischemia, necrosis, and non-healing ONJ lesions. Our finding adds to the current knowledge of the potential pathophysiologic mechanisms related to ONJ.
引用
收藏
页码：5 / 7
页数：3
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