Characteristics of CD5-Positive Splenic Marginal Zone Lymphoma with Leukemic Manifestation; Clinical, Flow Cytometry, and Histopathological Findings of 11 Cases

被引：13

作者：

Kojima, Minoru

Sato, Eriko ^{[3
]}

Oshimi, Kazuo ^{[3
]}

Murase, Takuhei ^{[4
]}

Koike, Tadashi ^{[5
]}

Tsunoda, Sinichirou ^{[6
]}

Matsumoto, Toshiharu ^{[7
]}

Marutsuka, Kousuke ^{[8
]}

Ogiya, Daisuke ^{[1
]}

Moriuchi, Makiko ^{[1
]}

Tokunaka, Mami ^{[2
]}

Kikuti, Yukie Yara ^{[2
]}

Kikuchi, Tomoki ^{[2
]}

Nakamura, Naoya ^{[2
]}

Ando, Kiyoshi ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Hematol & Oncol, Isehara, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa, Japan

[3] Juntendo Univ, Sch Med, Dept Hematol, Tokyo, Japan

[4] Nishio Municipal Hosp, Dept Internal Med, Nishio, Japan

[5] Nagaoka Red Cross Hosp, Nagaoka, Niigata, Japan

[6] Sakae Kyousai Hosp, Yokohama, Kanagawa, Japan

[7] Juntendo Univ, Sch Med, Dept Pathol, Tokyo, Japan

[8] Miyazaki Univ, Miyazaki Med Coll Hosp, Pathol Div, Miyazaki, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2010年 / 50卷 / 02期

关键词：

splenic marginal zone lymphoma; CD5; CD13; immunohistochemistry;

D O I：

10.3960/jslrt.50.107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Splenic marginal zone lymphoma (SP-MZL) is a rare low-grade B-cell neoplasm that often shows leukemic manifestation. Less than 20% of cases of SP-MZL express CD5. We analyzed 11 cases of CD5-positive SP-MZL with leukemic manifestation. The clinical characteristics of these cases did not differ from those of CD5-negative SP-MZL. Flow cytometry revealed positive results as follows : CD3, 0/9; CD5, 11/11; CD10, 0/11; CD11c, 4/10, CD13, 5/11; CD19, 11/11; CD20, 10/11; CD21, 4/4; CD22, 7/7; CD23, 5/10; CD25, 8/11; FMC7, 5/7; k type 6/9, and lambda type 2/9. All 3 cases with monoclonal gamma-globulinemia expressed CD13. Resected spleen exhibited a proliferation of neoplastic cells in white pulp in all 8 splenectomy patients and a marginal pattern was detected in 5 patients. Only 2 cases showed involvement of red pulp. Immunohistochemistry showed that the lymphoma cells were positive for CD5, CD20, and BCL-2 and negative for CD3, CD10, cyclin D1, BCL-6, and MUM-1 in all 11 cases. These results suggest that CD5-positive SP-MZL differs from B-cell chronic lymphocytic leukemia, that CD13 expression is found in about half of CD5-positive SP-MZL cases, and that CD5-positive SP-MZL may be related to memory B-cell neoplasm or plasma cell differentiation.

引用

页码：107 / 112

页数：6

共 1 条

[1] Clinicopathological features of CD5-positive splenic marginal zone lymphoma
Li, Yunling
Wang, Guannan
Liu, Enjie
Zhang, Dandan
Zhang, Yanping
Jian, Xiangyu
Zhao, Wugan
Li, Wencai
JOURNAL OF CLINICAL PATHOLOGY, 2024, 77 (06) : 421 - 425

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