I-125-LABELED 1-(2'-ACETYL-4'-[ORTHO-IODOBENZOYL]-AMINOPHENOXY)-3-ISOPROPYL-AMINOPROPAN-2-OL

被引：0

作者：

HANSON, RN ^{[1
]}

DAVIS, MA ^{[1
]}

HOLMAN, BL ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT RADIOL,JOINT PROGRAM NUCL MED,BOSTON,MA 02115

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 02期

关键词：

Beta Adrenergic Antagonist; Iodine‐125;

D O I：

10.1002/jlcr.2580160206

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of the iodine‐125 labeled beta adrenergic antagonist, 1‐ (2′‐acetyl‐4′‐[ortho‐iodobenzoyl] ‐aminophenoxy)‐3‐isopropylamino‐propan‐2‐ol, suitable for biodistribution studies is described. Synthesis of the unlabeled precursor proceeds in a 44% yield and the iodine‐125 exchange results in 89% incorporation of label. The final product is radiochemically pure (98‐99%) with a specific activity of 3.2 Ci/mmol. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：269 / 273

页数：5

共 10 条

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