TECHNIQUE FOR INVIVO PERFUSION OF CHEMOTHERAPEUTIC-AGENTS INTO THE RAT-LIVER

被引：8

作者：

RYAN, CJ

RYAN, S

WOOD, CB

BLUMGART, LH

机构：

[1] University Department of Surgery, Royal Infirmary, Glasgow, Scotland

来源：

JOURNAL OF SURGICAL RESEARCH | 1979年 / 26卷 / 02期

关键词：

D O I：

10.1016/0022-4804(79)90091-X

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The toxic side effects of many cancer chemotherapeutic agents prevent their use in high concentrations. This paper describes a technique for the administration of large doses of chemotherapeutic agents to the rat liver in an in vivo isolated perfusion system. This method is applicable for testing the effect of various agents on liver pathophysiology. No alteration in liver function, liver weight, or histological pattern was noted following perfusion with high concentrations of 5-fluorouracil. © 1979.

引用

页码：142 / 149

页数：8

共 6 条

[1] INHIBITION OF LIVER REGENERATION BY INTRAPORTAL INFUSION OF FRESH SERUM AFTER PARTIAL HEPATECTOMY IN RAT
BRADBROOK, RA
NEWCOMBE, RG
BLUMGART, LH
[J]. SCOTTISH MEDICAL JOURNAL, 1973, 18 (02) : 66 - 66
[2] BRAYSHAW BJ, 1971, MED LAB TECHNOL, V28, P133
[3] Higgins GM, 1931, ARCH PATHOL, V12, P186
[4] ISOLATION AND PERFUSION OF LIVER FOR CANCER CHEMOTHERAPY
MULCARE, RJ
SOLIS, A
FORTNER, JG
[J]. JOURNAL OF SURGICAL RESEARCH, 1973, 15 (02) : 87 - 95
[5] METABOLIC CHANGES FOLLOWING VARYING DEGREES OF PARTIAL HEPATECTOMY IN RAT
WOOD, CB
KARRAN, SJ
BLUMGART, LH
[J]. BRITISH JOURNAL OF SURGERY, 1973, 60 (08) : 613 - 617
[6] WOOD CB, UNPUBLISHED

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