INTERFERON-ALPHA AND INTERFERON-BETA DOWN-REGULATE THE EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN CARCINOMAS

被引：393
|
作者：
SINGH, RK [1 ]
GUTMAN, M [1 ]
BUCANA, CD [1 ]
SANCHEZ, R [1 ]
LLANSA, N [1 ]
FIDLER, IJ [1 ]
机构：
[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期
关键词：
ANGIOGENESIS;
D O I：
10.1073/pnas.92.10.4562
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Downregulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (>10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.
引用
收藏
页码：4562 / 4566
页数：5
相关论文
共 50 条
  • [21] CELL TYPE SPECIFIC EXPRESSION AND REGULATION OF MURINE INTERFERON-ALPHA AND INTERFERON-BETA GENES
    HOSSHOMFELD, A
    ZWARTHOFF, EC
    ZAWATZKY, R
    VIROLOGY, 1989, 173 (02) : 539 - 550
  • [22] DIFFERING CELL RESPONSES TO INTERFERON-GAMMA AND TO INTERFERON-ALPHA AND INTERFERON-BETA
    WALLACH, D
    FELLOUS, M
    SCHLUSSEL, R
    REVEL, M
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1982, 18 (06): : 21 - 21
  • [23] DEFINITION OF IMMUNOMODULATORY EFFECTS OF INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA
    BORDEN, EC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 179 - 179
  • [24] INTERFERON-ALPHA AND INTERFERON-GAMMA DOWN-REGULATE THE PRODUCTION OF INTERLEUKIN-8 AND ENA-78 IN HUMAN MONOCYTES
    SCHNYDERCANDRIAN, S
    STRIETER, RM
    KUNKEL, SL
    WALZ, A
    JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (06) : 929 - 935
  • [25] EFFECTS OF INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA ON HUMAN INTERLEUKIN-2 PRODUCTION
    ROSZTOCZY, I
    SIROKI, O
    BELADI, I
    JOURNAL OF INTERFERON RESEARCH, 1986, 6 (05): : 581 - 589
  • [26] INTERFERON-ALPHA BUT NOT INTERFERON-BETA GENES REQUIRE DENOVO PROTEIN-SYNTHESIS FOR EFFICIENT EXPRESSION IN HUMAN MONOCYTES
    GOBL, AE
    CEDERBLAD, B
    SANDBERG, K
    ALM, GV
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1992, 35 (02) : 177 - 185
  • [27] INFLUENCE OF INTERFERON-ALPHA, INTERFERON-BETA AND INTERFERON-DELTA ON FIBROBLASTS ATTACHMENT AND CHEMOTAXIS
    MENSING, H
    KORNER, C
    STEINKRAUS, V
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (04) : 443 - 443
  • [28] INTERFERON-ALPHA AND INTERFERON-BETA INDUCE IA EXPRESSION IN LIMITED PROTEIN-SYNTHESIS CONDITION
    KITAURA, M
    INABA, K
    INABA, M
    OGATA, H
    WATANABE, Y
    SHIMIZU, S
    IKEHARA, S
    MURAMATSU, S
    JOURNAL OF INTERFERON RESEARCH, 1990, 10 (05): : 487 - 496
  • [29] MECHANISMS FOR THE INHIBITION OF HIV REPLICATION BY INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA IN PRIMARY HUMAN MACROPHAGES
    MEYLAN, PRA
    GUATELLI, JC
    MUNIS, JR
    RICHMAN, DD
    KORNBLUTH, RS
    VIROLOGY, 1993, 193 (01) : 138 - 148
  • [30] INTERFERON-ALPHA OR INTERFERON-BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL-LINES
    STANZIONE, S
    CIMOLI, G
    DEBERNARDIS, D
    MICHELOTTI, A
    CONTE, PF
    PARODI, S
    RUSSO, P
    MUTATION RESEARCH LETTERS, 1995, 348 (03): : 131 - 135
12345