INTERFERON-ALPHA AND INTERFERON-BETA DOWN-REGULATE THE EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN CARCINOMAS

被引：393

作者：

SINGH, RK ^{[1
]}

GUTMAN, M ^{[1
]}

BUCANA, CD ^{[1
]}

SANCHEZ, R ^{[1
]}

LLANSA, N ^{[1
]}

FIDLER, IJ ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期

关键词：

ANGIOGENESIS;

D O I：

10.1073/pnas.92.10.4562

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Downregulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (>10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

引用

页码：4562 / 4566

页数：5

共 34 条

[1] NUCLEOTIDE-SEQUENCE OF A BOVINE CLONE ENCODING THE ANGIOGENIC PROTEIN, BASIC FIBROBLAST GROWTH-FACTOR [J].

ABRAHAM, JA ;

MERGIA, A ;

WHANG, JL ;

TUMOLO, A ;

FRIEDMAN, J ;

HJERRILD, KA ;

GOSPODAROWICZ, D ;

FIDDES, JC .

SCIENCE, 1986, 233 (4763) :545-548

[2]

ALLEY MC, 1988, CANCER RES, V48, P589

[3] A RAPID COLORIMETRIC INSITU MESSENGER-RNA HYBRIDIZATION TECHNIQUE USING HYPERBIOTINYLATED OLIGONUCLEOTIDE PROBES FOR ANALYSIS OF MDR1 IN MOUSE COLON-CARCINOMA CELLS [J].

BUCANA, CD ;

RADINSKY, R ;

DONG, ZY ;

SANCHEZ, R ;

BRIGATI, DJ ;

FIDLER, IJ .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (04) :499-506

[4] THE HEPARIN-BINDING (FIBROBLAST) GROWTH-FACTOR FAMILY OF PROTEINS [J].

BURGESS, WH ;

MACIAG, T .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :575-606

[5]

DVORAK HF, 1992, J NATL CANCER I, V81, P497

[6] INTERFERON ALFA-2A THERAPY FOR LIFE-THREATENING HEMANGIOMAS OF INFANCY [J].

EZEKOWITZ, RAB ;

MULLIKEN, JB ;

FOLKMAN, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (22) :1456-1463

[7] MODULATION OF THE INVASIVE PHENOTYPE OF HUMAN COLON-CARCINOMA CELLS BY ORGAN SPECIFIC FIBROBLASTS OF NUDE-MICE [J].

FABRA, A ;

NAKAJIMA, M ;

BUCANA, CD ;

FIDLER, IJ .

DIFFERENTIATION, 1992, 52 (01) :101-110

[8] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[9]

FIDLER IJ, 1990, CANCER RES, V50, P6130

[10]

Folkman J, 1992, Semin Cancer Biol, V3, P65

← 1 2 3 4 →