INTERFERON-ALPHA AND INTERFERON-BETA DOWN-REGULATE THE EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN CARCINOMAS

被引：393

作者：

SINGH, RK ^{[1
]}

GUTMAN, M ^{[1
]}

BUCANA, CD ^{[1
]}

SANCHEZ, R ^{[1
]}

LLANSA, N ^{[1
]}

FIDLER, IJ ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期

关键词：

ANGIOGENESIS;

D O I：

10.1073/pnas.92.10.4562

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Downregulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (>10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

引用

页码：4562 / 4566

页数：5

共 50 条

[1] INDUCTION OF INTERFERON-ALPHA BY INTERFERON-BETA, BUT NOT OF INTERFERON-BETA BY INTERFERON-ALPHA, IN THE MOUSE
ASANO, M
HAYASHI, M
YOSHIDA, E
KAWADE, Y
IWAKURA, Y
VIROLOGY, 1990, 176 (01) : 30 - 38
[2] Cell density-dependent modulation of basic fibroblast growth factor expression by human interferon-beta
Singh, RK
Bucana, CD
Llansa, N
Sanchez, R
Fidler, IJ
INTERNATIONAL JOURNAL OF ONCOLOGY, 1996, 8 (04) : 649 - 656
[3] ENTERIC ABSORPTION OF HUMAN INTERFERON-ALPHA AND INTERFERON-BETA IN THE RAT
BOCCI, V
CORRADESCHI, F
NALDINI, A
LENCIONI, E
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 34 (1-2) : 111 - 114
[4] CLONING OF INTERFERON-ALPHA AND MURINE INTERFERON-BETA
VODJANI, G
LEROSCOUET, D
HORTH, M
PERRUCA, DL
LEMAIGREDUBREUIL, Y
TOVEY, M
BRISON, O
LATTA, M
DOLY, J
ANNALES DE VIROLOGIE, 1984, 135 (03): : 306 - 306
[5] EXPRESSION OF INTERFERON-ALPHA AND INTERFERON-BETA GENES IN HUMAN-LYMPHOBLASTOID (NAMALWA) CELLS
SHUTTLEWORTH, J
MORSER, J
BURKE, DC
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 133 (02): : 399 - 404
[6] Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
Wittling, Megen C.
Cahalan, Shannon R.
Levenson, Eric A.
Rabin, Ronald L.
FRONTIERS IN IMMUNOLOGY, 2021, 11
[7] DIFFERENCE IN THE PRODUCTION OF HUMAN INTERFERON-ALPHA AND INTERFERON-BETA IN MOUSE CELLS
TOTH, MI
CENDSUREN, O
ENDRESZ, V
KARCAGI, I
DUDA, E
JOURNAL OF GENERAL VIROLOGY, 1988, 69 : 2527 - 2533
[8] INHIBITION OF LEUKOCYTE PROSTAGLANDIN METABOLISM BY HUMAN INTERFERON-ALPHA AND INTERFERON-BETA
DOREDUFFY, P
PERRY, W
FEDERATION PROCEEDINGS, 1982, 41 (03) : 559 - 559
[9] FIBROBLAST COLLAGEN PRODUCTION INHIBITORY LYMPHOKINE AND MONOKINE ARE INTERFERON-ALPHA AND INTERFERON-BETA RESPECTIVELY
DUNCAN, MR
BERMAN, B
CLINICAL RESEARCH, 1985, 33 (02): : A634 - A634
[10] DETERMINATION OF HUMAN INTERFERON-ALPHA, INTERFERON-BETA AND INTERFERON-GAMMA IN PLASMA AND OR PHARMACEUTICALS
NAITO, S
TANAKA, S
MIZUNO, M
KAWASHIMA, H
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 17 (01) : 109 - 114

← 1 2 3 4 5 →