TRAMTRACK ACTS DOWNSTREAM OF NUMB TO SPECIFY DISTINCT DAUGHTER CELL FATES DURING ASYMMETRIC CELL DIVISIONS IN THE DROSOPHILA PNS

被引：102

作者：

GUO, M

BIER, E

JAN, LY

JAN, YN

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,DEPT BIOCHEM,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093

[3] UNIV CALIF SAN DIEGO,CTR MOLEC GENET,LA JOLLA,CA 92093

来源：

NEURON | 1995年 / 14卷 / 05期

关键词：

D O I：

10.1016/0896-6273(95)90330-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Asymmetric eel divisions allow a sensory organ precursor (SOP) cell to generate a neuron and its support cells in the Drosophila PNS. We demonstrate a role of tramtrack (ttk), previously identified as a zinc finger-containing putative transcription factor, in the determination of different daughter cell fates. Both loss of function and overexpression of ttk affect the fates of the SOP progeny. Whereas loss of ttk function transforms support cells to neurons, ttk overexpression results in the reverse transformation. ttk is expressed in support cells but not in neurons. It has been shown that numb, a membrane-associated protein asymmetrically distributed during the SOP division, confers different daughter cell fates. Loss of ttk or numb function results in reciprocal cell fate transformation. Epistatic studies suggest that ttk acts downstream of numb. We propose that ttk executes the command dictated by asymmetrically localized numb to specify distinct daughter cell fates during multiple asymmetric divisions.

引用

页码：913 / 925

页数：13

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