BIDIRECTIONAL EFFECTS OF INTRATHECAL NMDA AND SUBSTANCE-P ON RAT DORSAL HORN NEURONAL RESPONSES

被引：16
作者：
CHAPMAN, V
DICKENSON, AH
TJOLSEN, A
机构：
[1] UCL, DEPT PHARMACOL, LONDON WC1E 6BT, ENGLAND
[2] UNIV BERGEN, DEPT PHYSIOL, N-5009 BERGEN, NORWAY
来源：
NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期
关键词：
RAT; DORSAL HORN; NOCICEPTION; N-METHYL-D-ASPARTATE; SUBSTANCE P;
D O I：
10.1016/0304-3940(94)90297-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and A delta-fibre evoked responses but not wind-up of convergent dorsal born neurones in the halothane anaesthetized rat. Higher doses of NMDA and SP (10-500 ng) were without effect. Co-administered SP (10 ng) with NMDA (5 ng) facilitated A delta-fibre evoked responses and wind-up. Excitatory amino acid and peptide interactions are discussed.
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页码：90 / 94
页数：5
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