RELATION BETWEEN MYOCARDIAL UPTAKE OF TL-201 CHLORIDE AND F-18 FLUORODEOXYGLUCOSE IMAGED WITH SINGLE-PHOTON EMISSION TOMOGRAPHY IN NORMAL INDIVIDUALS

Recently, we have demonstrated the feasibility of imaging myocardial uptake of fluorine-18 fluorodeoxyglucose (FDG) with single-photon emission tomography (SPET) using a specially designed collimator, Thallium-201 was used to determine distribution of perfusion for comparison with FDG uptake. However, regional Tl-201 and FDG activities may be different, based on differences in tracer attenuation and the use of different collimators. To study the relation between tracer activities imaged with SPET, nine healthy individuals underwent resting Tl-201 SPET and FDG SPET during a hyperinsulinaemic euglycaemic clamp. The SPET data were analysed semiquantitatively, using circumferential profiles. Mean profiles of midventricular short-axis slices showed no significant difference between Tl-201 and FDC activity. Regional fluctuations were similar for FDG and Tl-201; the highest tracer activities were observed in the lateral wall and the lowest activities in the septum. Finally, pooled data (n=1620 segmental activities) in nine individuals showed a linear correlation (P<0.0001) between Tl-201 and FDG activity: FDG=0.76 Tl-201 + 0.23 (r=0.70). These data demonstrate the absence of major differences between regional Tl-201 and FDG activity in normal myocardium, suggesting that no separate Tl-201 and FDG SPET reference values are needed for comparison with patient studies.