INFLUENCE OF FATTY-ACID BACKDIFFUSION ON COMPARTMENTAL ANALYSIS OF EXTERNAL DETECTION CURVES OBTAINED WITH 123-IODOHEXADECENOIC ACID IN ISOLATED RAT-HEART

被引：1
|
作者：
GARNIER, A [1 ]
DUBOIS, F [1 ]
KERIEL, C [1 ]
POIZAT, C [1 ]
CAND, F [1 ]
CUCHET, P [1 ]
机构：
[1] UNIV JOSEPH FOURIER,ETUD RADIOPHARMACEUT LAB,F-38041 GRENOBLE,FRANCE
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 03期
关键词：
D O I：
10.1016/0969-8051(93)90051-U
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
In isolated rat hearts, we investigated a possible backdiffusion of fatty acids and tried to determine whether it impaired our compartmental analysis of myocardial time-radioactivity curves obtained with an iodinated fatty acid, 16-iodo-9-hexadecenoic acid (IHA). Backdiffusion was not observed directly in the coronary effluents but was estimated by analysis of the external detection curves. Furthermore, when backdiffusion was not taken into account in the mathematical analysis, we obtained similar data on IHA intramyocardial metabolism.
引用
收藏
页码：297 / 306
页数：10
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