RAPID MONITORING OF CHANGES IN WATER DIFFUSION-COEFFICIENTS DURING REVERSIBLE ISCHEMIA IN CAT AND RAT-BRAIN

被引：147

作者：

DAVIS, D

ULATOWSKI, J

ELEFF, S

IZUTA, M

MORI, S

SHUNGU, D

VANZIJL, PCM

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT BIOPHYS,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,DIV NMR RES,MRI 110,BALTIMORE,MD 21287

来源：

MAGNETIC RESONANCE IN MEDICINE | 1994年 / 31卷 / 04期

关键词：

NMR SPECTROSCOPY; DIFFUSION; ISCHEMIA-REPERFUSION; CEREBRAL BLOOD FLOW;

D O I：

10.1002/mrm.1910310416

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Changes in the diffusion constant of water during reversible brain ischemia and cardiac arrest were monitored with a 10-s time resolution. Results (five cats, three rats) indicate that these changes are reversible and that the bulk of the changes are not caused by temperature or motion related to brain pulsations and blood flow. The rapid time course of the changes corresponds to the known time course for changes in energy state, signal transduction, and ionic homeostasis.

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页码：454 / 460

页数：7

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