DESIGN OF A FUNCTIONAL HEXAPEPTIDE ANTAGONIST OF ENDOTHELIN

被引：99
作者：
CODY, WL
DOHERTY, AM
HE, JX
DEPUE, PL
RAPUNDALO, ST
HINGORANI, GA
MAJOR, TC
PANEK, RL
DUDLEY, DT
HALEEN, SJ
LADOUCEUR, D
HILL, KE
FLYNN, MA
REYNOLDS, EE
机构：
[1] WARNER LAMBERT PARKE DAVIS,DEPT PHARMACOL,PARKE DAVIS PHARMACEUT RES DIV,ANN ARBOR,MI 48106
[2] WARNER LAMBERT PARKE DAVIS,DEPT SIGNAL TRANSDUCT,PARKE DAVIS PHARMACEUT RES DIV,ANN ARBOR,MI 48106
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 17期
关键词：
D O I：
10.1021/jm00095a029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：3301 / 3303
页数：3
相关论文
共 26 条
[1]   SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].
ARUNLAKSHANA, O ;
SCHILD, HO .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01) :48-58
[2]   CHIRAL SYNTHESIS OF D-3,3-DIPHENYLALANINE AND L-3,3-DIPHENYLALANINE (DIP), UNUSUAL ALPHA-AMINO-ACIDS FOR PEPTIDES OF BIOLOGICAL INTEREST [J].
CHEN, HG ;
BEYLIN, VG ;
MARLATT, M ;
LEJA, B ;
GOEL, OP .
TETRAHEDRON LETTERS, 1992, 33 (23) :3293-3296
[3]   MONOCYCLIC ENDOTHELINS - EXAMINATION OF THE IMPORTANCE OF THE INDIVIDUAL DISULFIDE RINGS [J].
CODY, WL ;
DOHERTY, AM ;
HE, XQ ;
RAPUNDALO, ST ;
HINGORANI, GP ;
PANEK, RL ;
MAJOR, TC .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1991, 17 :S62-S64
[4]   STRUCTURE ACTIVITY STUDIES OF THE C-TERMINAL REGION OF THE ENDOTHELINS AND THE SARAFOTOXINS [J].
DOHERTY, AM ;
CODY, WL ;
LEITZ, NL ;
DEPUE, PL ;
TAYLOR, MD ;
RAPUNDALO, ST ;
HINGORANI, GP ;
MAJOR, TC ;
PANEK, RL ;
TAYLOR, DG .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1991, 17 :S59-S61
[5]  
DOHERTY AM, 1992, 203RD NAT M AM CHEM
[6]  
GALANTINO M, 1992, PEPTIDES CHEM BIOL, P404
[7]  
HEMMI K, 1991, Patent No. 911075547
[8]  
HSIEH K, 1989, J MED CHEM, V32, P896
[9]   BIOLOGICAL PROFILES OF HIGHLY POTENT NOVEL ENDOTHELIN ANTAGONISTS SELECTIVE FOR THE ETA RECEPTOR [J].
IHARA, M ;
NOGUCHI, K ;
SAEKI, T ;
FUKURODA, T ;
TSUCHIDA, S ;
KIMURA, S ;
FUKAMI, T ;
ISHIKAWA, K ;
NISHIKIBE, M ;
YANO, M .
LIFE SCIENCES, 1992, 50 (04) :247-255
[10]   AN ENDOTHELIN RECEPTOR (ETA) ANTAGONIST ISOLATED FROM STREPTOMYCES-MISAKIENSIS [J].
IHARA, M ;
FUKURODA, T ;
SAEKI, T ;
NISHIKIBE, M ;
KOJIRI, K ;
SUDA, H ;
YANO, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 178 (01) :132-137
123