X-RAY STUDIES ON PHOSPHOLIPID-BILAYERS .11. INTERACTIONS WITH CHLORAMPHENICOL

被引：0
|
作者：
SUWALSKY, M
ESPINOZA, MA
SANCHEZ, I
VILLENA, F
机构：
[1] UNIV CONCEPCION, DEPT CHEM, CASILLA 3-C, CONCEPCION, CHILE
[2] UNIV CONCEPCION, DEPT HISTOL, CONCEPCION, CHILE
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 1991年 / 46卷 / 7-8期
关键词：
X-RAY DIFFRACTION; PHOSPHOLIPID BILAYER; ERYTHROCYTE MEMBRANE; CHLORAMPHENICOL;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chloramphenicol is a widely used antibiotic with low levels of toxicity. However, scanning electron microscopy revealed morphological changes in human erythrocytes when they interacted in vitro with therapeutical concentrations of chloramphenicol. To explain this shape change, a study concerned with the possible interactions of this antibiotic with bilayers built-up of phospholipids located in either side of the red cell membrane was performed by X-ray diffraction. Results indicated that chloramphenicol was unable to perturb in any significant extent the structure of the phospholipids under study. The only noticeable effects were phase transitions produced to dimyristoylphosphatidylethanolamine bilayers.
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页码：647 / 655
页数：9
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