A GENE FAMILY FOR ACIDIC RIBOSOMAL-PROTEINS IN SCHIZOSACCHAROMYCES-POMBE - 2 ESSENTIAL AND 2 NONESSENTIAL GENES

被引：47

作者：

BELTRAME, M ^{[1
]}

BIANCHI, ME ^{[1
]}

机构：

[1] UNIV PAVIA,DIPARTIMENTO GENET & MICROBIOL,I-27100 PAVIA,ITALY

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 05期

关键词：

D O I：

10.1128/MCB.10.5.2341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned the genes for small acidic ribosomal proteins ns) of the fission yeast Schizosaccharomyces pombe. S. pombe contains four transcribed genes for small A-proteins per haploid genome, as is the case for Saccharomyces cerevisiae. In contrast, multicellular eucaryotes contain two transcribed genes per haploid genome. The four proteins of S. pombe, besides sharing a high overall similarity, form two couples of nearly identical sequences. Their corresponding genes have a very conserved structure and are transcribed to a similar level. Surprisingly, of each couple of genes coding for nearly identical proteins, one is essential for cell growth, whereas the other is not. We suggest that the unequal importance of the four small A-proteins for cell survival is related to their physical organization in 60S ribosomal subunits.

引用

页码：2341 / 2348

页数：8

共 43 条

[1] 2 GENES FOR RIBOSOMAL PROTEIN-51 OF SACCHAROMYCES-CEREVISIAE COMPLEMENT AND CONTRIBUTE TO THE RIBOSOMES [J].

ABOVICH, N ;

ROSBASH, M .

MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (09) :1871-1879

[2] HIGH-FREQUENCY TRANSFORMATION OF THE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE [J].

BEACH, D ;

NURSE, P .

NATURE, 1981, 290 (5802) :140-142

[3] SEQUENCE OF THE CDNA FOR ONE ACIDIC RIBOSOMAL-PROTEIN OF SCHIZOSACCHAROMYCES-POMBE [J].

BELTRAME, M ;

BIANCHI, ME .

NUCLEIC ACIDS RESEARCH, 1987, 15 (21) :9089-9089

[4]

COHEN C, 1986, TRENDS BIOCHEM SCI, V11, P137

[5] IDENTIFICATION AND CHEMICAL SYNTHESIS OF A RIBOSOMAL-PROTEIN ANTIGENIC DETERMINANT IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

ELKON, K ;

SKELLY, S ;

PARNASSA, A ;

MOLLER, W ;

DANHO, W ;

WEISSBACH, H ;

BROT, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7419-7423

[6] PARALLEL ASSOCIATION OF FOS AND JUN LEUCINE ZIPPERS JUXTAPOSES DNA-BINDING DOMAINS [J].

GENTZ, R ;

RAUSCHER, FJ ;

ABATE, C ;

CURRAN, T .

SCIENCE, 1989, 243 (4899) :1695-1699

[7]

Gutz H., 1974, HDB GENETICS, V1, P395

[8] C-JUN DIMERIZES WITH ITSELF AND WITH C-FOS, FORMING COMPLEXES OF DIFFERENT DNA-BINDING AFFINITIES [J].

HALAZONETIS, TD ;

GEORGOPOULOS, K ;

GREENBERG, ME ;

LEDER, P .

CELL, 1988, 55 (05) :917-924

[9] CONSTITUTIVE TRANSCRIPTION OF YEAST RIBOSOMAL-PROTEIN GENE TCM1 IS PROMOTED BY UNCOMMON CIS-ACTING AND TRANS-ACTING ELEMENTS [J].

HAMIL, KG ;

NAM, HG ;

FRIED, HM .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (10) :4328-4341

[10] COMPLIATION AND COMPARISON OF THE SEQUENCE CONTEXT AROUND THE AUG STARTCODONS IN SACCHAROMYCES-CEREVISIAE MESSENGER-RNAS [J].

HAMILTON, R ;

WATANABE, CK ;

DEBOER, HA .

NUCLEIC ACIDS RESEARCH, 1987, 15 (08) :3581-3593

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