CHEMOTHERAPY OF EXPERIMENTAL ECHINOCOCCUS-MULTILOCULARIS IN JIRDS

被引:23
作者
VANPARIJS, O
机构
[1] Department of Parasitology, Janssen Pharmaceutica, Beerse
来源
PARASITOLOGY RESEARCH | 1990年 / 76卷 / 03期
关键词
D O I
10.1007/BF00930820
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
A total of 50 jirds (Meriones unguiculatus) were infected by intraperitoneal implantation of 0.20 g metacestode tissue of Echinococcus multilocularis. The feed of 4 groups of 10 animals each was treated for 35 days with 500 ppm albendazole, flubendazole, mebendazole or praziquantel; 1 group of 10 jirds served as unmedicated controls. At autopsy 2 weeks after the end of medication, the transplants had increased in size and weight, reaching a total weight of 78.11 g in the control group, 21.60 g in the albendazole-treated group, 3.63 g in the flubendazole-treated group, 7.00 g in the mebendazole-treated group and 68.91 g in the praziquantel-treated group. The percentage in reduction of parasitic tissue weight as compared with control values was 72%, 95%, 91% and 12%, respectively. The calculated daily drug intake was approximately 48 mg/kg body weight. Drug-related side effects were not observed. © 1990 Springer-Verlag.
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页码:238 / 240
页数:3
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