PC1 DUARTE, A COMMON POLYMORPHISM OF A HUMAN-BRAIN PROTEIN, AND ITS RELATIONSHIP TO DEPRESSIVE DISEASE AND MULTIPLE-SCLEROSIS

被引：64

作者：

COMINGS, DE

机构：

[1] Department of Medical Genetics, City of Hope National Medical Center, Duarte

来源：

NATURE | 1979年 / 277卷 / 5691期

关键词：

D O I：

10.1038/277028a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PC 1 Duarte, a common variant of a human brain-specific protein, is present in one-third of the control population and has a gene frequency of 0.17. There was a significantly increased frequency of mutant heterozygotes and homozygotes among individuals with depressive disease. This is consistent with a model in which Pc 1 Duarte is the major gene in depressive disease, acting in conjunction with an environmental threshold effect. © 1979 Nature Publishing Group.

引用

页码：28 / 32

页数：5

共 44 条

[1]

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[2]

BOOK J A, 1953, Acta Genet Stat Med, V4, P1

[3] DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN MAMMALIAN BRAIN - POSSIBLE SITE OF ACTION OF ANTIPSYCHOTIC-DRUGS [J].