Fucosylation and gastrointestinal cancer

被引：87

作者：

Moriwaki, Kenta ^{[1
]}

Miyoshi, Eiji ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Mol Biochem & Clin Invest, 1-7 Yamada Oka, Suita, Osaka 5650871, Japan

来源：

WORLD JOURNAL OF HEPATOLOGY | 2010年 / 2卷 / 04期

关键词：

Fucosylation; Gastrointestinal cancer; Alpha-fetoprotein;

D O I：

10.4254/wjh.v2.i4.151

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fucose (6-deoxy-L-galactose) is a monosaccharide that is found on glycoproteins and glycolipids in verte-brates, invertebrates, plants, and bacteria. Fucos-ylation, which comprises the transfer of a fucose residue to oligosaccharides and proteins, is regulated by many kinds of molecules, including fucos-yltransferases, GDP-fucose synthetic enzymes, and GDP-fucose transporter(s). Dramatic changes in the expression of fucosylated oligosaccharides have been observed in cancer and inflammation. Thus, monoclonal antibodies and lectins recognizing cancer-associated fucosylated oligosaccharides have been clinically used as tumor markers for the last few decades. Recent advanced glycomic approaches allow us to identify novel fucosylation-related tumor markers. Moreover, a growing body of evidence supports the functional significance of fucosylation at various pathophysiological steps of carcinogenesis and tumor progression. This review highlights the biological and medical significance of fucosylation in gastrointestinal cancer. (C) 2010 Baishideng. All rights reserved.

引用

页码：151 / 161

页数：11

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