Agastaquinone, a new cytotoxic diterpenoid quinone from Agastache rugosa

被引：26

作者：

Lee, HK

Oh, SR

Kim, JI

Kim, JW

Lee, CO

机构：

[1] SEOUL NATL UNIV,COLL PHARM,SEOUL 151742,SOUTH KOREA

[2] KOREA RES INST CHEM TECHNOL,TAEJON 305606,SOUTH KOREA

来源：

JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 11期

关键词：

D O I：

10.1021/np50125a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diterpenoid quinone, agastaquinone [1], was isolated from the roots of Agastache rugosa. An oxime derivative [2] of agastaquinone was prepared with hydroxylamine hydrochloride. The structure of agastaquinone [1] was established as 7-hydroxy-12-methoxy-20-norabieta-1,5(10),6,8,12-pentaene-3,11,14-trione by spectroscopic techniques. Compounds 1 and 2 showed nonspecific cytotoxic activities against several human cancer cell lines in vitro (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15).

引用

页码：1718 / 1721

页数：4

共 18 条

[1]

CHUNG BS, 1990, ENCY KOREAN CRUDE DR, P840

[2]

CHUNG TH, 1956, FLORA KOREA, V2, P536

[3] MISCELLANEOUS CONTRIBUTIONS TO ESSENTIAL OILS OF PLANTS FROM VARIOUS TERRITORIES .29. ESSENTIAL OIL OF AGASTACHE RUGOSA O KUNTZE .5. SESQUITERPENE HYDROCARBONS IN OIL [J].

FUJITA, S ;

FUJITA, Y .

YAKUGAKU ZASSHI, 1972, 92 (07) :908-&

[4]

Han D. S, 1987, KOR J PHARMACOG, V18, P50

[5]

HAN DS, 1987, KOR J PHARMACOG, V18, P99

[6]

HAN DS, 1988, KOR J PHARMACOG, V19, P97

[7]

HUR J, 1986, DONG I BO GAM, P741

[8]

ITOKAWA H, 1981, CHEM PHARM BULL, V29, P1777

[9]

KATSUDA Y, 1965, JPN J CHEM, V86, P635

[10]

LEE CB, 1980, KOREAN FLORA, P649

← 1 2 →