SYNTHESIS OF (+)-VERNOLEPIN RELATED-COMPOUNDS FROM GERMACRANOLIDES

被引：11

作者：

BARRERO, AF

OLTRA, JE

BARRAGAN, A

机构：

[1] Dto. de Química Orgánica, Facultad de Ciencias, 18071 Granada, Campus Fuentenueva s/n

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02238-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-8-O-acetyl-1,2,11,13-tetrahydro-8-epi -vernolepin (11) was synthesized from salonitenolide (4). The key steps were the Cope rearrangement of the germacradiene skeleton to elemadiene and the long-range functionalization at C-14, which allows the intramolecular cyclisation necessary for the formation of the delta-lactone ring of 11.

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页码：311 / 314

页数：4

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