EFFECT OF ACETYL-L-CARNITINE ON LIPID-PEROXIDATION AND XANTHINE-OXIDASE ACTIVITY IN RAT SKELETAL-MUSCLE

被引：62

作者：

DIGIACOMO, C

LATTERI, F

FICHERA, C

SORRENTI, V

CAMPISI, A

CASTORINA, C

RUSSO, A

PINTURO, R

VANELLA, A

机构：

[1] UNIV CATANIA,INST BIOCHEM,V A DORIA 6,I-95125 CATANIA,ITALY

[2] UNIV CATANIA,INST SURG PATHOL,I-95125 CATANIA,ITALY

[3] UNIV CATANIA,CHAIR RHEUMATOL,I-95125 CATANIA,ITALY

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 11期

关键词：

LIPOPEROXIDATION; ACETYL-L-CARNITINE; XANTHINE OXIDASE;

D O I：

10.1007/BF00978367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been reported that acetyl-L-carnitine (AcCn) can reduce the degenerative processes in the central nervous system of rats, modify the fluidity of membranes and decrease the accumulation of lipofuscins in neurones. In light of these considerations we have assayed the in vitro effect of acetyl-L-carnitine on spontaneous and induced lipoperoxidation in rat skeletal muscle; in addition, the effect of AcCn on XD/XO ratio was evaluated. The presence of AcCn (10-40 mM) in incubation medium significantly reduced MDA and conjugated diene formation in rat skeletal muscle; moreover, a significant decrease in induced MDA levels was observed when microsomal preparation where incubated in the presence of 10-40 mM AcCn. Since a significant reduction of XO activity was detected in the presence of 10-80 mM AcCn, the reduced lipid peroxidation by AcCn seems to be due to an inhibition of XO activity.

引用

页码：1157 / 1162

页数：6

共 34 条

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