DETERMINATION OF THE HEROIN METABOLITE 6-MONOACETYL-MORPHINE IN URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：12
作者：
HANISCH, W
MEYER, LV
机构：
[1] Institut für Rechtsmedizin, München 2, 8000
来源：
JOURNAL OF ANALYTICAL TOXICOLOGY | 1993年 / 17卷 / 01期
关键词：
D O I：
10.1093/jat/17.1.48
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A procedure has been developed for detection and quantitation of 6-monoecetylmorphine (6-MAM), the specific metebolite of heroin in human urine. 6-MAM was isolated by solid-phase extraction, and the extracts were analyzed by high-performance liquid chromatography with electrochemical detection in the oxidizing mode. Good linearity was obtained in the concentration range 10–250 ng/mL. Concentrations of 2 ng 6-MAM/mL can be detected using a 2-mL sample of urine. The method has been verified in urine samples of heroin abusers. © 1993 Oxford University Press.
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页码：48 / 50
页数：3
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