INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY PYRIMIDO-PYRIMIDINE DERIVATIVES IN HUMAN LIVER MEMBRANES

被引：96

作者：

DELACRUZ, JP

CARRASCO, T

ORTEGA, G

DELACUESTA, FS

机构：

[1] Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Málaga

来源：

LIPIDS | 1992年 / 27卷 / 03期

关键词：

D O I：

10.1007/BF02536177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of pyrimido-pyrimidine derivatives (dipyridamole, RA-642, and RA-233) on lipid peroxidation, using d-alpha-tocopherol as standard, were studied in enriched membrane fractions from human and rat hepatocytes. Equimolar concentrations of ferrous sulfate and ascorbic acid were used to induce lipid peroxidation. The amount of peroxidized lipids observed in membrane fractions from human liver was smaller than in those from rat liver. In both species, however, pyrimido-pyrimidine derivatives, except for RA-233 in rat liver, inhibited lipid peroxidation dose-dependently in the following sequence: RA-642 > dipyridamole > d-alpha-tocopherol RA-233.

引用

页码：192 / 194

页数：3

共 21 条

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[2]

BOSMANN HB, 1969, STRUCTURE FUNCTION N, P1

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