RGD-CONTAINING PEPTIDES OF VP1 OF FOOT-AND-MOUTH-DISEASE VIRUS (FMDV) PREVENT VIRUS-INFECTION INVITRO

被引：0

作者：

LIEBERMANN, H ^{[1
]}

DOLLING, R ^{[1
]}

SCHMIDT, D ^{[1
]}

THALMANN, G ^{[1
]}

机构：

[1] INST WIRKSTOFFORSCH,W-1136 BERLIN,GERMANY

来源：

ACTA VIROLOGICA | 1991年 / 35卷 / 01期

关键词：

FOOT-AND-MOUTH DISEASE VIRUS; SYNTHETIC PEPTIDES; AMINO ACID SEQUENCE RGD; INVITRO BLOCKING OF VIRUS INFECTION;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RGD-containing peptides from the immunodominant region of VP1 between amino acids 135 - 160 from foot-and-mouth disease virus (FMDV) type O1 Kaufbeuren (O1K) prevented virus adsorption to piglet kidnex (PK) cells. The highly conserved amino acid RGD sequence (Arg.-Gly.-Asp.) was a prerequisite of this effect. To prevent infection with 100 - 200 TCID50 in 10(6) PK cells, 20 - 250-mu-g of each peptide should have been added.

引用

页码：90 / 93

页数：4

共 13 条

[1] PROTECTION AGAINST FOOT-AND-MOUTH-DISEASE BY IMMUNIZATION WITH A CHEMICALLY SYNTHESIZED PEPTIDE PREDICTED FROM THE VIRAL NUCLEOTIDE-SEQUENCE [J].