TETRODOTOXIN AND RELATED SUBSTANCES IN A RIBBON WORM CEPHALOTHRIX-LINEARIS (NEMERTEAN)

被引：56
作者：
ALI, AE
ARAKAWA, O
NOGUCHI, T
MIYAZAWA, K
SHIDA, Y
HASHIMOTO, K
机构：
[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN
[2] HIROSHIMA UNIV,FAC APPL BIOL SCI,HIROSHIMA 724,JAPAN
[3] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN
[4] IBARAKI UNIV,FAC EDUC,FOOD SCI LAB,MITO,IBARAKI 310,JAPAN
来源：
TOXICON | 1990年 / 28卷 / 09期
关键词：
D O I：
10.1016/0041-0101(90)90147-Y
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A ribbon worm Cephalothrix linearis (Nemertean) showed a high toxicity, of up to 22,000 MU/g proboscis and 13,600 MU/g body, in terms of tetrodotoxin. This organism secreted the toxin from the skin when wiped with gauze. The toxin was partially purified from the secretion as well as the wiped body by ultrafiltration and Bio-Gel P-2 column chromatography. Thin-layer chromatographic, electrophoretic, high performance liquid chromatographic, and gas chromatography-mass spectrometric analyses showed that the secreted toxin was composed almost exclusively of a tetrodonic acidic-like substance, whereas the remaining toxin in the wiped body consisted of the said substance and tetrodotoxin. © 1990.
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页码：1083 / 1093
页数：11
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