GENETICALLY MODIFIED CELLS - APPLICATIONS FOR INTRACEREBRAL GRAFTING

被引：123

作者：

GAGE, FH

KAWAJA, MD

FISHER, LJ

机构：

[1] Dept of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0624

来源：

TRENDS IN NEUROSCIENCES | 1991年 / 14卷 / 08期

关键词：

D O I：

10.1016/0166-2236(91)90156-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Grafting cells to the CNS is a useful approach to address fundamental and clinical issues in neurobiology. Recently, a hybrid technique - the genetic modification of cells followed by intracerebral implantation - has emerged, which may potentially enhance the power of CNS grafting. However, several methodological considerations need to be addressed to test the reliability of this new approach. Progress in the gene transfer-grafting technique has implications for expanding the range of issues and problems that may be addressed in both the basic science and clinical arenas.

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页码：328 / 333

页数：6

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