Synthesis, Reaction and Antiviral Activity of 2,4-Diaryl-1,3-selenazoles

被引：9

作者：

Al-Rubaie, Ali Z. ^{[1
]}

Al-Masoudi, Wasfi A. ^{[2
,5
]}

Hameed, Ali Jameel ^{[1
]}

Yousif, Lina Z. ^{[1
]}

Graia, Mohsen ^{[3
,4
]}

机构：

[1] Univ Basrah, Coll Sci, Dept Chem, Basrah, Iraq

[2] Al Mergab Univ, Coll Arts & Sci, Dept Chem, Tarhona, Libya

[3] Fac Sci Tunis, Lab Mate & Cristallochim, Tunis 2029, Tunisia

[4] Inst Preparatoire Etud Ingn Sfax, Sfax, Tunisia

[5] Al Mergab Univ, Coll Arts & Sci Tarhona, Dept Chem, Tarhona, Libya

来源：

JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE | 2008年 / 52卷 / 01期

关键词：

1,3-Selenazoles; arylselenocarboxamides; alpha-bromoketones; X-ray; HIV-1;

D O I：

10.5012/jkcs.2008.52.1.036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cyclization of primary arylselenocarboxylic amides with a-bromoketones afforded a variety of new 2,4-diaryl-1,3-selenazoles. Halogenation of the 2,4-diaryl-1,3-selenazoles with chlorine, bromine and iodine gave the new 1,1-dihalo-2,4-diaryl-1,3-selenazoles in good yields. Antiviral activity of some 1,1-dihalo-2,4-diaryl-1,3-selenazoles has been tested against AIDS virus (HIV-1 and HIV-2). They showed some bioactivity against HIV-1. All compounds were characterized by their elemental analysis, H-1 NMR and mass spectroscopic data. The crystal structure of 2-(3,4dimethoxyphenyl)- 4-(4-bromophenyl)-1,3-selenazole displays the molecular configuration.

引用

页码：36 / 46

页数：11

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