Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus

被引：10

作者：

Ahn, Ji Hyeon ^{[1
,2
]}

Lee, Joon Seok ^{[3
,4
]}

Cho, Jun Hwi ^{[3
,4
]}

Park, Joon Ha ^{[1
,2
]}

Lee, Tae-Kyeong ^{[5
]}

Song, Minah ^{[5
]}

Kim, Hyunjung ^{[5
]}

Kang, Seok Hoon ^{[6
]}

Won, Moo-Ho ^{[5
]}

Lee, Choong Hyun ^{[7
]}

机构：

[1] Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon, South Korea

[2] Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 24252, Gangwon, South Korea

[3] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Emergency Med, Chunchon 24341, Gangwon, South Korea

[4] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Inst Med Sci, Chunchon 24341, Gangwon, South Korea

[5] Kangwon Natl Univ, Sch Med, Dept Neurobiol, 1 Kangwondaehak Gil, Chunchon 24341, Gangwon, South Korea

[6] Kangwon Natl Univ, Dept Med Educ, Sch Med, Chunchon 24341, Gangwon, South Korea

[7] Dankook Univ, Dept Pharm, Coll Pharm, 119 Dandae Ro, Cheonan 31116, Chungcheongnam, South Korea

来源：

BIOMEDICAL REPORTS | 2018年 / 8卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

aging; cognitive function; gerbil; hippocampus; nuclear receptor related-1 protein;

D O I：

10.3892/br.2018.1094

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Nuclear receptor related-1 protein (Nurr1) serves important roles in hippocampal-dependent cognitive process. In the present study, the protein expression of Nurr1 was compared in the hippocampi of young [postnatal month 3 (PM 3)], adult (PM 12) and aged (PM 24) gerbils using western blot analysis and immunohistochemistry. Results indicated that the protein level of Nurr1 was significantly and gradually decreased in the gerbil hippocampus with increasing age. In addition, strong Nurr1 immunoreactivity was primarily observed in pyramidal neurons and granule cells of the hippocampus in the young group, which was determined to be reduced in the adult group and to a greater extent in the aged group. Collectively the data demonstrated that Nurr1 immunoreactivity was gradually and markedly decreased during normal aging. These results indicate that gradual decrease of Nurr1 expression in the hippocampus may be associated with the normal aging process and a decline in hippocampus-dependent cognitive function.

引用

页码：517 / 522

页数：6

共 41 条

[1] Long-term observation of neuronal degeneration and microgliosis in the gerbil dentate gyrus after transient cerebral ischemia [J].